Cerebellar and frontal hypometabolism in alcoholic cerebellar degeneration studied with positron emission tomography
dc.contributor.author | Gilman, Sid | en_US |
dc.contributor.author | Adams, Kenneth M. | en_US |
dc.contributor.author | Koeppe, Robert A. | en_US |
dc.contributor.author | Berent, Stanley | en_US |
dc.contributor.author | Kluin, Karen J. | en_US |
dc.contributor.author | Modell, Jack G. | en_US |
dc.contributor.author | Kroll, Phillip D. | en_US |
dc.contributor.author | Brunberg, James A. | en_US |
dc.date.accessioned | 2007-04-06T18:53:32Z | |
dc.date.available | 2007-04-06T18:53:32Z | |
dc.date.issued | 1990-12 | en_US |
dc.identifier.citation | Gilman, Sid; Adams, Kenneth; Koeppe, Robert A.; Berent, Stanley; Kluin, Karen J.; Modell, Jack G.; Kroll, Phillip; Brunberg, James A. (1990)."Cerebellar and frontal hypometabolism in alcoholic cerebellar degeneration studied with positron emission tomography." Annals of Neurology 28(6): 775-785. <http://hdl.handle.net/2027.42/50340> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50340 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2285264&dopt=citation | en_US |
dc.description.abstract | Local cerebral metabolic rate for glucose was studied utilizing 18 F-2-fluoro-2-deoxy-D-glucose and positron emission tomography (PET) in 14 chronically alcohol-dependent patients and 8 normal control subjects of similar age and sex. Nine of the 14 patients (Group A) had clinical signs of alcoholic cerebellar degeneration, and the remaining 5 (Group B) did not have signs of alcoholic cerebellar degeneration. PET studies of Group A revealed significantly decreased local cerebral metabolic rates for glucose in the superior cerebellar vermis in comparison with the normal control subjects. Group B did not show decreased rates in the cerebellum. Both Groups A and B showed decreased local cerebral metabolic rates for glucose bilaterally in the medial frontal area of the cerebral cortex in comparison with the normal control subjects. The severity of the clinical neurological impairment was significantly correlated with the degree of hypometabolism in both the superior cerebellar vermis and the medial frontal region of the cerebral cortex. The degree of atrophy detected in computed tomography scans was significantly correlated with local cerebral metabolic rates in the medial frontal area of the cerebral cortex, but not in the cerebellum. The data indicate that hypometabolism in the superior cerebellar vermis closely follows clinical symptomatology in patients with alcoholic cerebellar degeneration, and does not occur in alcohol-dependent patients without clinical evidence of cerebellar dysfunction. Hypometabolism in the medial frontal region of the cerebral cortex is a prominent finding in alcohol-dependent patients with or without alcoholic cerebellar degeneration. | en_US |
dc.format.extent | 2090310 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Cerebellar and frontal hypometabolism in alcoholic cerebellar degeneration studied with positron emission tomography | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, and the Veterans Affairs Medical Center, Ann Arbor, MI ; Department of Neurology, The University of Michigan, 1914 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0316 | en_US |
dc.contributor.affiliationum | Department of Psychiatry, The University of Michigan, and the Veterans Affairs Medical Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, The University of Michigan, and the Veterans Affairs Medical Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, and the Veterans Affairs Medical Center, Ann Arbor, MI ; Department of Psychiatry, The University of Michigan, and the Veterans Affairs Medical Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Physical Medicine and Rehabilitation, The University of Michigan, and the Veterans Affairs Medical Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Psychiatry, The University of Michigan, and the Veterans Affairs Medical Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Psychiatry, The University of Michigan, and the Veterans Affairs Medical Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, and the Veterans Affairs Medical Center, Ann Arbor, MI ; Department of Radiology, The University of Michigan, and the Veterans Affairs Medical Center, Ann Arbor, MI | en_US |
dc.identifier.pmid | 2285264 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50340/1/410280608_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410280608 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.