Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy
dc.contributor.author | McDonald, John W. | en_US |
dc.contributor.author | Garofalo, Elizabeth A. | en_US |
dc.contributor.author | Hood, Terry W. | en_US |
dc.contributor.author | Sackellares, J. Chris | en_US |
dc.contributor.author | Gilman, Sid | en_US |
dc.contributor.author | McKeever, Paul E. | en_US |
dc.contributor.author | Troncoso, Juan C. | en_US |
dc.contributor.author | Johnston, Michael V. | en_US |
dc.date.accessioned | 2007-04-06T18:53:50Z | |
dc.date.available | 2007-04-06T18:53:50Z | |
dc.date.issued | 1991-05 | en_US |
dc.identifier.citation | McDonald, John W.; Garofalo, Elizabeth A.; Hood, Terry; Sackellares, J. Chris; Gilman, Sid; McKeever, Paul E.; Troncoso, Juan C.; Johnston, Michael V. (1991)."Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy." Annals of Neurology 29(5): 529-541. <http://hdl.handle.net/2027.42/50343> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50343 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1650160&dopt=citation | en_US |
dc.description.abstract | We examined binding to excitatory amino acid and inhibitory amino acid receptors in frozen hippocampal sections prepared from surgical specimens resected from 8 individuals with medically refractory temporal lobe epilepsy. The excitatory receptors studied included N -methyl-D-aspartate (NMDA), strychnine-insensitive glycine, phencyclidine, and quisqualate. The inhibitory receptors studied were gamma-aminobutyric acid type A (GABA A ) and benzodiazepine. Excitatory and inhibitory amino acid receptor binding were differentially altered in the patients with temporal lobe epilepsy in comparison to 8 age-comparable autopsy control subjects, and changes in receptor binding were regionally selective in four areas. Binding to phencyclidine receptors associated with the NMDA channel was reduced by 35 to 70% in all regions in the hippocampi of the patients. In contrast, binding to the NMDA recognition site and its associated glycine modulatory site was elevated by 20 to 110% in the cornu ammonis (CA) 1 area and dentate gyrus of the hippocampus of the patients. Binding to these sites was unaffected in area CA4. Binding to the quisqualate-type excitatory amino acid receptor was unchanged in all regions except the stratum lacunosum moleculare CA1, where it was increased by 63%. GABA A and benzodiazepine receptor binding was reduced by 20 to 60% in CA1 and CA4, but unchanged in dentate gyrus. The data indicate that excitatory and inhibitory amino acid receptors are altered in the hippocampus of patients with temporal lobe epilepsy. | en_US |
dc.format.extent | 1571894 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurosurgery, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Department of Pathology, Johns hopkins University School of Medicine, Baltimore, MD | en_US |
dc.contributor.affiliationother | Department of Neurology and Pediatrics Johns hopkins University School of Medicine, Baltimore, MD ; Department of Kennedy Institute, Baltimore, MD ; The Kennedy Institute, Room 506, 707 North Broadway, Baltimore, MD 21205 | en_US |
dc.identifier.pmid | 1650160 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50343/1/410290513_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410290513 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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