Show simple item record

Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy

dc.contributor.authorMcDonald, John W.en_US
dc.contributor.authorGarofalo, Elizabeth A.en_US
dc.contributor.authorHood, Terry W.en_US
dc.contributor.authorSackellares, J. Chrisen_US
dc.contributor.authorGilman, Siden_US
dc.contributor.authorMcKeever, Paul E.en_US
dc.contributor.authorTroncoso, Juan C.en_US
dc.contributor.authorJohnston, Michael V.en_US
dc.date.accessioned2007-04-06T18:53:50Z
dc.date.available2007-04-06T18:53:50Z
dc.date.issued1991-05en_US
dc.identifier.citationMcDonald, John W.; Garofalo, Elizabeth A.; Hood, Terry; Sackellares, J. Chris; Gilman, Sid; McKeever, Paul E.; Troncoso, Juan C.; Johnston, Michael V. (1991)."Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy." Annals of Neurology 29(5): 529-541. <http://hdl.handle.net/2027.42/50343>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50343
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1650160&dopt=citationen_US
dc.description.abstractWe examined binding to excitatory amino acid and inhibitory amino acid receptors in frozen hippocampal sections prepared from surgical specimens resected from 8 individuals with medically refractory temporal lobe epilepsy. The excitatory receptors studied included N -methyl-D-aspartate (NMDA), strychnine-insensitive glycine, phencyclidine, and quisqualate. The inhibitory receptors studied were gamma-aminobutyric acid type A (GABA A ) and benzodiazepine. Excitatory and inhibitory amino acid receptor binding were differentially altered in the patients with temporal lobe epilepsy in comparison to 8 age-comparable autopsy control subjects, and changes in receptor binding were regionally selective in four areas. Binding to phencyclidine receptors associated with the NMDA channel was reduced by 35 to 70% in all regions in the hippocampi of the patients. In contrast, binding to the NMDA recognition site and its associated glycine modulatory site was elevated by 20 to 110% in the cornu ammonis (CA) 1 area and dentate gyrus of the hippocampus of the patients. Binding to these sites was unaffected in area CA4. Binding to the quisqualate-type excitatory amino acid receptor was unchanged in all regions except the stratum lacunosum moleculare CA1, where it was increased by 63%. GABA A and benzodiazepine receptor binding was reduced by 20 to 60% in CA1 and CA4, but unchanged in dentate gyrus. The data indicate that excitatory and inhibitory amino acid receptors are altered in the hippocampus of patients with temporal lobe epilepsy.en_US
dc.format.extent1571894 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titleAltered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurosurgery, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationotherDepartment of Pathology, Johns hopkins University School of Medicine, Baltimore, MDen_US
dc.contributor.affiliationotherDepartment of Neurology and Pediatrics Johns hopkins University School of Medicine, Baltimore, MD ; Department of Kennedy Institute, Baltimore, MD ; The Kennedy Institute, Room 506, 707 North Broadway, Baltimore, MD 21205en_US
dc.identifier.pmid1650160en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50343/1/410290513_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410290513en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.