Parametric in vivo imaging of benzodiazepine receptor distribution in human brain
dc.contributor.author | Frey, Kirk A. | en_US |
dc.contributor.author | Holthoff, Vjera A. | en_US |
dc.contributor.author | Koeppe, Robert A. | en_US |
dc.contributor.author | Jewett, Douglas M. | en_US |
dc.contributor.author | Kilbourn, Michael R. | en_US |
dc.contributor.author | Kuhl, David E. | en_US |
dc.date.accessioned | 2007-04-06T18:54:16Z | |
dc.date.available | 2007-04-06T18:54:16Z | |
dc.date.issued | 1991-11 | en_US |
dc.identifier.citation | Frey, Kirk A.; Holthoff, Vjera A.; Koeppe, Robert A.; Jewett, Douglas M.; Kilbourn, Michael R.; Kuhl, David E. (1991)."Parametric in vivo imaging of benzodiazepine receptor distribution in human brain." Annals of Neurology 30(5): 663-672. <http://hdl.handle.net/2027.42/50347> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50347 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1662476&dopt=citation | en_US |
dc.description.abstract | Emission computed tomographic methods for the in vivo quantification of radioligand-binding sites in human brain have previously been limited either by a lack of correction for possible effects of altered ligand transport or by highly complicated physiological models that preclude display of binding data in a detailed anatomical format. We investigated the application of a simplified compartmental model to the kinetic analysis of in vivo ligand binding to central benzodiazepine receptors. The human brain distribution of { 11 C}flumazenil, as determined by dynamic positron emission tomography, combined with metabolite-corrected arterial blood samples, permitted estimations of local cerebral ligand transport and of receptor binding. This approach allows calculation of transport and binding “maps” on a pixel-by-pixel basis, resulting in the display of binding data in a familiar tomographic format while maintaining much of the physiological accuracy inherent in more complex methods. The results obtained in a study of 6 normal volunteers revealed good interindividual precision, with coefficients of variation between 10 and 15% of mean regional values, suggesting the utility of this approach in future clinical studies of benzodiazepine receptor binding. | en_US |
dc.format.extent | 1028310 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Parametric in vivo imaging of benzodiazepine receptor distribution in human brain | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MI ; Mental Health Research Institute, University of Michigan, Ann Arbor, MI ; Division of Nuclear Medicine, B1 G412 University Hospital, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0028 | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Max-Planck-Institut fÜr Neurologische Forschung, KÖln, Federal Republic of Germany | en_US |
dc.identifier.pmid | 1662476 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50347/1/410300506_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410300506 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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