Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease
dc.contributor.author | Albin, Roger L. | en_US |
dc.contributor.author | Reiner, Anton | en_US |
dc.contributor.author | Anderson, Keith D. | en_US |
dc.contributor.author | Dure, Leon S. IV | en_US |
dc.contributor.author | Handelin, Barbara | en_US |
dc.contributor.author | Balfour, Rosemary | en_US |
dc.contributor.author | Whetsell, William O. | en_US |
dc.contributor.author | Penney, John B. | en_US |
dc.contributor.author | Young, Anne B. | en_US |
dc.date.accessioned | 2007-04-06T18:54:29Z | |
dc.date.available | 2007-04-06T18:54:29Z | |
dc.date.issued | 1992-04 | en_US |
dc.identifier.citation | Albin, Roger L.; Reiner, Anton; Anderson, Keith D.; Dure, Leon S.; Handelin, Barbara; Balfour, Rosemary; Whetsell, William O.; Penney, John B.; Young, Anne B. (1992)."Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease." Annals of Neurology 31(4): 425-430. <http://hdl.handle.net/2027.42/50349> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50349 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1375014&dopt=citation | en_US |
dc.description.abstract | We have reported previously that striatal projection neurons are differentially affected in the course of Huntington's disease, and in a prior patient report we noted that differential loss of striatal projection neurons occurs also in patients with presymptomatic Huntington's disease. Striatal neurons projecting to the external segment of the globus pallidus or the substantia nigra show evident loss, whereas those projecting to the internal segment of the globus pallidus appear relatively spared at presymptomatic and early stages of symptomatic Huntington's disease. We now report similar findings in a second apparently presymptomatic Huntington's disease allele carrier. | en_US |
dc.format.extent | 2158381 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI ; Neuroscience Laboratory Building, 1103 E. Huron, Ann Arbor, MI 48104 | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Department of Anatomy and Neurobiology, University of Tennessee, Health Science Center, Memphis | en_US |
dc.contributor.affiliationother | Department of Anatomy and Neurobiology, University of Tennessee, Health Science Center, Memphis | en_US |
dc.contributor.affiliationother | Department of Integrated Genetics, Framingham, MA | en_US |
dc.contributor.affiliationother | Department of Integrated Genetics, Framingham, MA | en_US |
dc.contributor.affiliationother | Department of Pathology, Vanderbilt University, Nashville, TN | en_US |
dc.identifier.pmid | 1375014 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50349/1/410310412_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410310412 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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