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dc.contributor.authorAlbin, Roger L.en_US
dc.contributor.authorReiner, Antonen_US
dc.contributor.authorAnderson, Keith D.en_US
dc.contributor.authorDure, Leon S. IVen_US
dc.contributor.authorHandelin, Barbaraen_US
dc.contributor.authorBalfour, Rosemaryen_US
dc.contributor.authorWhetsell, William O.en_US
dc.contributor.authorPenney, John B.en_US
dc.contributor.authorYoung, Anne B.en_US
dc.date.accessioned2007-04-06T18:54:29Z
dc.date.available2007-04-06T18:54:29Z
dc.date.issued1992-04en_US
dc.identifier.citationAlbin, Roger L.; Reiner, Anton; Anderson, Keith D.; Dure, Leon S.; Handelin, Barbara; Balfour, Rosemary; Whetsell, William O.; Penney, John B.; Young, Anne B. (1992)."Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease." Annals of Neurology 31(4): 425-430. <http://hdl.handle.net/2027.42/50349>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50349
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1375014&dopt=citationen_US
dc.description.abstractWe have reported previously that striatal projection neurons are differentially affected in the course of Huntington's disease, and in a prior patient report we noted that differential loss of striatal projection neurons occurs also in patients with presymptomatic Huntington's disease. Striatal neurons projecting to the external segment of the globus pallidus or the substantia nigra show evident loss, whereas those projecting to the internal segment of the globus pallidus appear relatively spared at presymptomatic and early stages of symptomatic Huntington's disease. We now report similar findings in a second apparently presymptomatic Huntington's disease allele carrier.en_US
dc.format.extent2158381 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titlePreferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's diseaseen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI ; Neuroscience Laboratory Building, 1103 E. Huron, Ann Arbor, MI 48104en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationotherDepartment of Anatomy and Neurobiology, University of Tennessee, Health Science Center, Memphisen_US
dc.contributor.affiliationotherDepartment of Anatomy and Neurobiology, University of Tennessee, Health Science Center, Memphisen_US
dc.contributor.affiliationotherDepartment of Integrated Genetics, Framingham, MAen_US
dc.contributor.affiliationotherDepartment of Integrated Genetics, Framingham, MAen_US
dc.contributor.affiliationotherDepartment of Pathology, Vanderbilt University, Nashville, TNen_US
dc.identifier.pmid1375014en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50349/1/410310412_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410310412en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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