Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging
dc.contributor.author | Frey, Kirk A. | en_US |
dc.contributor.author | Koeppe, Robert A. | en_US |
dc.contributor.author | Kilbourn, Michael R. | en_US |
dc.contributor.author | Vander Borght, Thierry M. | en_US |
dc.contributor.author | Albin, Roger L. | en_US |
dc.contributor.author | Gilman, Sid | en_US |
dc.contributor.author | Kuhl, David E. | en_US |
dc.date.accessioned | 2007-04-06T18:55:52Z | |
dc.date.available | 2007-04-06T18:55:52Z | |
dc.date.issued | 1996-12 | en_US |
dc.identifier.citation | Frey, Kirk A.; Koeppe, Robert A.; Kilbourn, Michael R.; Vander Borght, Thierry M.; Albin, Roger L.; Gilman, Sid; Kuhl, David E. (1996)."Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging." Annals of Neurology 40(6): 873-884. <http://hdl.handle.net/2027.42/50362> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50362 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9007092&dopt=citation | en_US |
dc.description.abstract | We present development and human application of a method for determining the regional cerebral density of the type 2 vesicular monoamine transporter (VMAT2) using positron emission tomography (PET) and [ 11 C]dihydrotetrabenazine (DTBZ). Previous animal studies indicate striatal VMAT2 density is linearly related to the integrity of substantia nigra dopamine neurons and is not subject to drug-or lesion-compensatory regulation. In the present studies, kinetic compartmental modeling was employed to estimate blood-brain [ 11 C]DTBZ transport ( K 1 ,) and VMAT2 binding site density (tissue-to-plasma DTBZ distribution volume, DV )from the cerebral and plasma DTBZ time courses her intravenous tracer injection. In controls, we found reductions of putamen DTBZ DV with advancing age, corresponding to losses of 0.77% per year in specific VMAT2 binding. Parkinson's disease (PD) patients had reduction in specific DTBZ DV in the putamen (−61%) and in the caudate nucleus (−43%). There was no overlap of lowest specific putamen DTBZ DV between individual elderly controls and PD patients. The present results indicate the suitability of [ 11 C]DTBZ PET for objective quantification of nigrostriatal integrity, including evaluation of PD progression and its possible therapeutic modification. | en_US |
dc.format.extent | 1211812 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine (Division of Nuclear Medicine), University of Michigan, Ann Arbor, MI ; Departments of Neurology, University of Michigan, Ann Arbor, MI ; Departments of Mental Health Research Institute, University of Michigan, Ann Arbor, MI ; The University of Michigan Hospitals, B1G 412/0028 AGH, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0028 | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine (Division of Nuclear Medicine), University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine (Division of Nuclear Medicine), University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine (Division of Nuclear Medicine), University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.identifier.pmid | 9007092 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50362/1/410400609_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410400609 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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