Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference
Foster, Norman L.; Wilhelmsen, Kirk C.; Sima, Anders A. F.; Jones, Margaret Z.; D'Amato, Constance J.; Gilman, Sid
1997-06
Citation
Foster, Norman L.; Wilhelmsen, Kirk; Sima, Anders A. F.; Jones, Margaret Z.; D'Amato, Constance J.; Gilman, Sid (1997)."Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference." Annals of Neurology 41(6): 706-715. <http://hdl.handle.net/2027.42/50364>
Abstract
We held an international consensus conference on frontotemporal dementia, behavioral disturbances, and parkinsonism linked to chromosome 17 to determine whether these are homogeneous or heterogeneous disorders, to agree on terminology, and to develop strategies for further research. The group identified 13 kindreds with sufficient evidence for linkage, finding in common to all a critical 2 cM between markers D17S791 and D17S800. There was agreement that (1) despite previous descriptions that have emphasized one or another clinical or neuropathological feature, the kindreds share clinical and neuropathological features; (2) until more specific information about the genetic defects becomes available, this disorder is best termed frontotemporal dementia and parkinsonism linked to chromosome 17 ; and (3) further research will be enhanced by identifying the gene responsible for this disorder, detecting additional cases within known families and, in new families, correlating mutations with phenotypes and more fully delineating the clinical, neuropsychological, and neuropathological characteristics of this disorder.Publisher
Wiley Subscription Services, Inc., A Wiley Company
ISSN
0364-5134 1531-8249
Other DOIs
PMID
9189031
Types
Article
Metadata
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