Imaging epileptogenic tubers in children with tuberous sclerosis complex usingΑ-[ 11 C]Methyl- L -tryptophan positron emission tomography
dc.contributor.author | Chugani, Diane C. | en_US |
dc.contributor.author | Chugani, Harry T. | en_US |
dc.contributor.author | Muzik, Otto | en_US |
dc.contributor.author | Shah, Jagdish R. | en_US |
dc.contributor.author | Shah, Aashit K. | en_US |
dc.contributor.author | Canady, Alexa | en_US |
dc.contributor.author | Mangner, Thomas J. | en_US |
dc.contributor.author | Chakraborty, Pulak K. | en_US |
dc.date.accessioned | 2007-04-06T18:56:32Z | |
dc.date.available | 2007-04-06T18:56:32Z | |
dc.date.issued | 1998-12 | en_US |
dc.identifier.citation | Chugani, Diane C.; Chugani, Harry T.; Muzik, Otto; Shah, Jagdish R.; Shah, Aashit K.; Canady, Alexa; Mangner, Thomas J.; Chakraborty, Pulak K. (1998)."Imaging epileptogenic tubers in children with tuberous sclerosis complex usingΑ-[ 11 C]Methyl- L -tryptophan positron emission tomography." Annals of Neurology 44(6): 858-866. <http://hdl.handle.net/2027.42/50368> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50368 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9851429&dopt=citation | en_US |
dc.description.abstract | Several reports have indicated that cortical resection is effective in alleviating intractable epilepsy in children with tuberous sclerosis complex (TSC). Because of the multitude of cortical lesions, however, identifying the epileptogenic tuber(s) is difficult and often requires invaise intracranial electroencephalographic (EEG) monitoring. As increased concentrations of serotonin and serotonin-immunoreactive processes have been reported in resected human epileptic cortex, we used Α-[ 11 C]methyl-L-tryptophan ([ 11 C]AMT) position emission tomography (PET) to test the hypothesis that serotonin synthesis is increased interictally in epileptogenic tubers in patients with TSC. Nine children with TSC and epilepsy, aged 1 to 9 years (mean, 4 years 1 month), were studied. All children underwent scalp video-EEG monitoring, PET scans of glucose metabolism and serotonin synthesis, and EEG monitoring during both PET studies. [ 11 C]AMT scans were coregistred with magnetic resonance imaging and with glucose metabolism scans. Whereas glucose metabolism PET showed multifocal cortical hypometabolism corresponding to the locations of tubers in all 9 children, [ 11 C]AMT uptake was increased in one tuber (n = 3), two tubers (n = 3), three tubers (n = 1), and four tubers (n = 1) in 8 of the 9 children. All other tubers showed decreased [ 11 C]AMT uptake. Ictal EEG data available in 8 children showed seizure onset corresponding to foci of increased [ 11 C]AMT uptake in 4 children (including 2 with intracranial EEG recordings). In 2 children, ictal EEG was nonlocalizing, and in 1 child there was discordance between the region of increased [ 11 C]AMT uptake and the region of ictal onset on EEG. The only child whose [ 11 C]AMT scan showed to no regions of increased uptake had a left frontal seizure focus on EEG; however, at the time of his [ 11 C]AMT PET scan, his seizures had come under control. [ 11 C]AMT PET may be a powerful tool in differentiating between epileptogenic and nonepileptogenic tubers in patients with TSC. | en_US |
dc.format.extent | 1389310 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Imaging epileptogenic tubers in children with tuberous sclerosis complex usingΑ-[ 11 C]Methyl- L -tryptophan positron emission tomography | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Childern's Hospital of Michigan and Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI ; Department of Radiology, Childern's Hospital of Michigan and Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Childern's Hospital of Michigan and Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI ; Department of Radiology, Childern's Hospital of Michigan and Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI ; Department of Neurology, Childern's Hospital of Michigan and Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI ; PET Center, Children's Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201 | en_US |
dc.contributor.affiliationother | Department of Radiology, Childern's Hospital of Michigan and Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI | en_US |
dc.contributor.affiliationother | Department of Neurology, Childern's Hospital of Michigan and Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI | en_US |
dc.contributor.affiliationother | Department of Neurology, Childern's Hospital of Michigan and Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, Childern's Hospital of Michigan and Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI | en_US |
dc.contributor.affiliationother | Department of Radiology, Childern's Hospital of Michigan and Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI | en_US |
dc.contributor.affiliationother | Department of Radiology, Childern's Hospital of Michigan and Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI | en_US |
dc.identifier.pmid | 9851429 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50368/1/410440603_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410440603 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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