Ultrastructure of spontaneous and transplanted pituitary tumors in laboratory animals
dc.contributor.author | Lloyd, Ricardo V. | en_US |
dc.date.accessioned | 2007-04-06T18:58:46Z | |
dc.date.available | 2007-04-06T18:58:46Z | |
dc.date.issued | 1991-09 | en_US |
dc.identifier.citation | Lloyd, Ricardo V. (1991)."Ultrastructure of spontaneous and transplanted pituitary tumors in laboratory animals." Journal of Electron Microscopy Technique 19(1): 64-79. <http://hdl.handle.net/2027.42/50389> | en_US |
dc.identifier.issn | 0741-0581 | en_US |
dc.identifier.issn | 1553-0817 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50389 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1960572&dopt=citation | en_US |
dc.description.abstract | The present review examines ultrastructural studies of pituitary tumors in laboratory animals. Such studies have been facilitated by the development of newer techniques such as immunocytochemistry and in situ hybridization. Using these methods it has been possible to correlate morphological features with function by characterizing specific pituitary hormones in secretory granules and analyzing the messenger ribonucleic acids produced by specific cell types. Analyses of spontaneous and experimentally induced tumors have provided a great deal of insight into the function and ultrastructure of these neoplasms. The description of tumor cells producing more than one hormone has been facilitated by immunocytochemical analyses. Studies of transgenic models of pituitary hyperplasia and tumor development are expanding our knowledge about the ultrastructure and about other aspects of pituitary tumors in a more controlled experimental setting. The production of various hormones by the same pituitary tumors and even the same tumor cells indicates that complex regulatory mechanisms must be analyzed by a combination of ultrastructural and other techniques to learn more about growth and hormone secretion in pituitary neoplasms. | en_US |
dc.format.extent | 2620435 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Ultrastructure of spontaneous and transplanted pituitary tumors in laboratory animals | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Science (General) | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 ; Department of Pathology, University of Michigan Hospitals, 2G332/Box 0054, Ann Arbor, Michigan 48109–0054 | en_US |
dc.identifier.pmid | 1960572 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50389/1/1060190107_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jemt.1060190107 | en_US |
dc.identifier.source | Journal of Electron Microscopy Technique | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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