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dc.contributor.authorRaphael, Yehoashen_US
dc.contributor.authorAltschuler, Richard A.en_US
dc.date.accessioned2007-04-06T19:00:16Z
dc.date.available2007-04-06T19:00:16Z
dc.date.issued1991en_US
dc.identifier.citationRaphael, Yehoash; Altschuler, Richard A. (1991)."Reorganization of cytoskeletal and junctional proteins during cochlear hair cell degeneration." Cell Motility and the Cytoskeleton 18(3): 215-227. <http://hdl.handle.net/2027.42/50403>en_US
dc.identifier.issn0886-1544en_US
dc.identifier.issn1097-0169en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50403
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1711932&dopt=citationen_US
dc.description.abstractExperiments were carried out to elucidate changes in cytoskeletal elements and intercellular junctions in the organ of Corti, when hair cells degenerate and phalangeal scars form. Hair cell damage was induced by exposing guinea pigs to high intensity noise. The spatial and temporal changes in the organization of micro-filaments, intermediate filaments, and tight junction-specific proteins were investigated using scanning and transmission electron microscopy and histochemistry. The results show that microfilaments, cytokeratins, adherens junctions, and tight junctions rearrange their distribution in damaged areas. From the temporal sequence of these changes it appears that phalangeal scars develop simultaneous with hair cell degeneration, and that the integrity of the luminal membranes in the organ of Corti is not interrupted. Each scar is formed by two supporting cells which expand and invade the sub-apical region of the dying hair cell. This region becomes cytokeratin-positive. The two supporting cells meet at the mid-line of the scar, where a new junctional complex is formed. The junctional complex consists of tight junction and adherens-type junction, but desmosomes are absent.en_US
dc.format.extent1347681 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleReorganization of cytoskeletal and junctional proteins during cochlear hair cell degenerationen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumKresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor ; Kresge Hearing Research Institute, University of Michigan, 1301 E. Ann Street, Ann Arbor, MI 48109-0506en_US
dc.contributor.affiliationumKresge Hearing Research Institute, University of Michigan Medical School, Ann Arboren_US
dc.identifier.pmid1711932en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50403/1/970180307_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/cm.970180307en_US
dc.identifier.sourceCell Motility and the Cytoskeletonen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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