In vivo imaging of monoaminergic nerve terminals in normal and MPTP-lesioned primate brain using positron emission tomography (PET) and [ 11 C]tetrabenazine
dc.contributor.author | DaSilva, Jean N. | en_US |
dc.contributor.author | Kilbourn, Michael R. | en_US |
dc.contributor.author | Domino, Edward F. | en_US |
dc.date.accessioned | 2007-04-06T19:00:29Z | |
dc.date.available | 2007-04-06T19:00:29Z | |
dc.date.issued | 1993-06 | en_US |
dc.identifier.citation | DaSilva, Jean N.; Kilbourn, Michael R.; Domino, Edward F. (1993)."In vivo imaging of monoaminergic nerve terminals in normal and MPTP-lesioned primate brain using positron emission tomography (PET) and [ 11 C]tetrabenazine." Synapse 14(2): 128-131. <http://hdl.handle.net/2027.42/50405> | en_US |
dc.identifier.issn | 0887-4476 | en_US |
dc.identifier.issn | 1098-2396 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50405 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8332945&dopt=citation | en_US |
dc.description.abstract | The first successful in vivo imaging of monoamine vesicular transporters in the living primate brain is described, using [ 11 C]tetrabenazine ([ 11 C]TBZ) and Positron Emission Tomography (PET). Radioligand uptake into brain is rapid, and at short time periods (10-30 minutes) the higher uptake and retention of the radiotracer in the more densely dopaminergic innervated striatum is clearly visualized. Specific binding in striatum can be entirely blocked with co-administration of a pharmacological dose (1 mg/kg i. v.) of tetrabenazine. In a unilaterally MPTP-lesioned monkey, specific binding of radioligand was absent in the striatum on the lesioned side, with no effect on radiotracer distribution in the cortex, cerebellum or contralateral striatum. PET imaging with [ 11 C]TBZ provides a new approach to the in vivo study of monoaminergic neurons and their loss in neurodegenerative diseases. © 1993 Wiley-Liss, Inc. | en_US |
dc.format.extent | 813010 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | In vivo imaging of monoaminergic nerve terminals in normal and MPTP-lesioned primate brain using positron emission tomography (PET) and [ 11 C]tetrabenazine | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine University of Michigan Center, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine University of Michigan Center, Ann Arbor, Michigan 48109 ; 3480 Kresge III, University of Michigan, Ann Arbor, MI 48109-0552 | en_US |
dc.contributor.affiliationum | Department of Pharmacology (E. F. D.), University of Michigan Center, Ann Arbor, Michigan 48109 | en_US |
dc.identifier.pmid | 8332945 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50405/1/890140205_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/syn.890140205 | en_US |
dc.identifier.source | Synapse | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.