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Relationship between asymmetries in striatal dopamine release and the direction of amphetamine-induced rotation during. The first week following a unilateral 6-OHDA lesion of the substantia nigra

dc.contributor.authorRobinson, Terry E.en_US
dc.contributor.authorNoordhoorn, Mauraen_US
dc.contributor.authorChan, Emily M.en_US
dc.contributor.authorMocsary, Zoltanen_US
dc.contributor.authorCamp, Dianne M.en_US
dc.contributor.authorWhishaw, Ian Q.en_US
dc.date.accessioned2007-04-06T19:00:35Z
dc.date.available2007-04-06T19:00:35Z
dc.date.issued1994-05en_US
dc.identifier.citationRobinson, Terry E.; Noordhoorn, Maura; Chan, Emily M.; Mocsary, Zoltan; Camp, Dianne M.; Whishaw, Ian Q. (1994)."Relationship between asymmetries in striatal dopamine release and the direction of amphetamine-induced rotation during. The first week following a unilateral 6-OHDA lesion of the substantia nigra." Synapse 17(1): 16-25. <http://hdl.handle.net/2027.42/50406>en_US
dc.identifier.issn0887-4476en_US
dc.identifier.issn1098-2396en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50406
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8042143&dopt=citationen_US
dc.description.abstractIn animals with a large unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal dopamine (DA) system the traditional “rotational behavior model” states that amphetamine will induce circling behavior towards the denervated striatum (ipsiversive), that is, away from the side where there is greater amphetamine-stimulated DA release and greater DA receptor stimulation. It is puzzling, therefore, why amphetamine induces contraversive rotation in rats tested 4 days after a unilateral 6-OHDA lesion, despite a 90-95% loss of the dopaminergic input to the striatum by this time. Rats reverse their direction of amphetamine-induced rotation by 8 days post-lesion and turn in the ipsiversive direction thereafter. To try and resolve this paradox, bilateral striatal microdialysis was used to estimate the effects of amphetamine on DA neurotransmission on Day 4 and Day 8 following a large unilateral 6-OHDA lesion of the substantia nigra. On Day 4 post-lesion, amphetamine produced a moderate (around 50% of control) increase in the extracellular concentration of DA in the denervated striatum. This amphetamine-releasable pool of DA was exhausted by a single amphetamine challenge, because a second injection of amphetamine given 3 h after the first did not produce a comparable increase in DA. It is suggested that on Day 4 post-lesion the amount of DA released by amphetamine in the denervated striatum is sufficient to produce greater DA receptor stimulation on that side, because of DA receptor supersensitivity, and this leads to contraversive rotation. On Day 8 post-lesion, amphetamine induced DA release in the intact striatum but had no effect on extracellular DA in the denervated striatum (DA was nondetectable). On Day 8, therefore, DA receptor stimulation would be greatest in the intact striatum, leading to ipsiversive rotation. In conclusion, it is suggested that the seemingly paradoxical reversal in the direction of amphetamine-induced rotation that occurs over the first week following a unilateral 6-OHDA lesion is consistent with the traditional rotational model, and is due to time-dependent changes in the ability of amphetamine to release DA in the denervated striatum. © 1994 Wiley-Liss, Inc.en_US
dc.format.extent1128780 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleRelationship between asymmetries in striatal dopamine release and the direction of amphetamine-induced rotation during. The first week following a unilateral 6-OHDA lesion of the substantia nigraen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48104-1687 ; Neuroscience Laboratory Building, The University of Michigan, 1103 East Huron Street, Ann Arbor, MI 48104-1687en_US
dc.contributor.affiliationumDepartment of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48104-1687en_US
dc.contributor.affiliationumDepartment of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48104-1687en_US
dc.contributor.affiliationumDepartment of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48104-1687en_US
dc.contributor.affiliationumDepartment of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48104-1687en_US
dc.contributor.affiliationotherDepartment of Psychology, University of Lethbridge, Lethbridge AB, Canadaen_US
dc.identifier.pmid8042143en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50406/1/890170103_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/syn.890170103en_US
dc.identifier.sourceSynapseen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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