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dc.contributor.authorWomble, Mark D.en_US
dc.contributor.authorMoises, Hylan C.en_US
dc.date.accessioned2007-04-06T19:00:42Z
dc.date.available2007-04-06T19:00:42Z
dc.date.issued1994-06en_US
dc.identifier.citationWomble, Mark D.; Moises, Hylan C. (1994)."Metabotropic glutamate receptor agonist ACPD inhibits some, but not all, muscarinic-sensitive K + conductances in basolateral amygdaloid neurons." Synapse 17(2): 69-75. <http://hdl.handle.net/2027.42/50407>en_US
dc.identifier.issn0887-4476en_US
dc.identifier.issn1098-2396en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50407
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8091303&dopt=citationen_US
dc.description.abstractMuscarinic agonists produce membrane depolarization and losses of spike frequency accommodation and the slow afterhyperpolarization (AHP) when applied to neurons of the basolateral amygdala (BLA). Underlying these changes are the muscarinic-induced inhibitions of several K + conductances, including the voltage-activated M-current (I M ), a slowly decaying Ca 2 -activated current (I AHP ), a voltage-insensitive leak current (I Leak ), and the hyperpolarization-activated inward rectifier current (I IR ) Similar depolarizations and losses of the slow AHP have been observed in other neuronal cell types following stimulation of metabotropic glutamate receptors. Therefore, we tested the effects of the metabotropic glutamate receptor agonist, 1-aminocyclopentanels, 3r-dicarboxylic acid (ACPD), on pyramidal neurons impaled with a single microelectrode for current- and voltage-clamp recordings in a brain slice preparation of the rat BLA. Application of ACPD (20 or 100 ΜM) to BLA neurons inhibited I M and I A HP , resulting in membrane depolarization and reductions in the amplitude and duration of the slow AHP. However, ACPD did not inhibit the muscarinic-sensitive current I IR , nor was I Leak blocked in the majority of neurons examined. These findings suggest the possibility that muscarinic cholinergic and metabotropic glutamatergic receptor agonists may activate separate intracellular transduction pathways which have convergent inhibitory effects onto I M and I AHP in BLA pyramidal neurons. © 1994 Wiley-hiss, Inc.en_US
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dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleMetabotropic glutamate receptor agonist ACPD inhibits some, but not all, muscarinic-sensitive K + conductances in basolateral amygdaloid neuronsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Physiology, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0622en_US
dc.contributor.affiliationumDepartment of Physiology, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0622en_US
dc.identifier.pmid8091303en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50407/1/890170202_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/syn.890170202en_US
dc.identifier.sourceSynapseen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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