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Amphetamine-Induced time-dependent sensitization of dopamine neurotransmission in the dorsal and ventral striatum: A microdialysis study in behaving rats

dc.contributor.authorPaulson, Pamela E.en_US
dc.contributor.authorRobinson, Terry E.en_US
dc.date.accessioned2007-04-06T19:00:48Z
dc.date.available2007-04-06T19:00:48Z
dc.date.issued1995-01en_US
dc.identifier.citationPaulson, Pamela E.; Robinson, Terry E. (1995)."Amphetamine-Induced time-dependent sensitization of dopamine neurotransmission in the dorsal and ventral striatum: A microdialysis study in behaving rats." Synapse 19(1): 56-65. <http://hdl.handle.net/2027.42/50408>en_US
dc.identifier.issn0887-4476en_US
dc.identifier.issn1098-2396en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50408
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7709344&dopt=citationen_US
dc.description.abstractThe purpose of this study was to compare the effects of amphetamine exposure on subsequent amphetamine-induced changes in behavior and dopamine (DA) release in the dorsal and ventral striatum, as a function of time following the discontinuation of repeated amphetamine treatment. Rats were pretreated with either saline or an escalating-dose amphetamine regimen, and then received a 0.5 mg/kg amphetamine “challenge” after either 3, 7, or 28 days of withdrawal. Animals tested after 28 days of withdrawal were hypersensitive (sensitized) to the locomotor-activating effects of amphetamine, and relative to control animals showed a significant enhancement in amphetamine-stimulated DA release in both the dorsal and ventral striatum, as revealed by in vivo microdialysis. Animals tested after only 3 or 7 days of withdrawal showed neither behavioral sensitization nor enhanced amphetamine-stimulated DA release. These results establish that time-dependent changes in behavioral sensitization to amphetamine are associated with time-dependent changes in amphetamine-stimulated DA release, and support the hypothesis that persistent sensitization-related changes in striatal DA neurotransmission contribute to the expression of behavioral sensitization. © 1995 Wiley-Liss, Inc.en_US
dc.format.extent1159288 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleAmphetamine-Induced time-dependent sensitization of dopamine neurotransmission in the dorsal and ventral striatum: A microdialysis study in behaving ratsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48104-1687en_US
dc.contributor.affiliationumDepartment of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48104-1687 ; Neuroscience Bldg., 1103 E. Huron St., Ann Arbor, MI 48104-1687en_US
dc.identifier.pmid7709344en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50408/1/890190108_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/syn.890190108en_US
dc.identifier.sourceSynapseen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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