Electrophoretic mobility and molecular distribution studies of poly(amidoamine) dendrimers of defined charges
dc.contributor.author | Shi, Xiangyang | en_US |
dc.contributor.author | Bányai, István | en_US |
dc.contributor.author | Rodriguez, Keyla | en_US |
dc.contributor.author | Islam, Mohammad T. | en_US |
dc.contributor.author | Lesniak, Wojciech | en_US |
dc.contributor.author | Balogh, Peter | en_US |
dc.contributor.author | Balogh, Lajos P. | en_US |
dc.contributor.author | Baker, James R. Jr. | en_US |
dc.date.accessioned | 2007-05-02T14:15:51Z | |
dc.date.available | 2007-05-02T14:15:51Z | |
dc.date.issued | 2006-05 | en_US |
dc.identifier.citation | Shi, Xiangyang; BÁnyai, IstvÁn; Rodriguez, Keyla; Islam, Mohammad T.; Lesniak, Wojciech; Balogh, Peter; Balogh, Lajos P.; Baker, James R. (2006). "Electrophoretic mobility and molecular distribution studies of poly(amidoamine) dendrimers of defined charges." Electrophoresis 27(9): 1758-1767. <http://hdl.handle.net/2027.42/50647> | en_US |
dc.identifier.issn | 0173-0835 | en_US |
dc.identifier.issn | 1522-2683 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50647 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16586414&dopt=citation | en_US |
dc.description.abstract | Generation 5 ethylenediamine (EDA)-cored poly(amidoamine) (PAMAM) dendrimers (E5, E denotes the EDA core and 5 the generation number) with different degrees of acetylation and carboxylation were synthesized and used as a model system to investigate the effect of charge and the influence of dendrimer surface modifications on electrophoretic mobility (EM) and molecular distribution. The surface-modified dendrimers were characterized by size-exclusion chromatography, 1 H NMR, MALDI-TOF-MS, PAGE, and CE. The focus of our study was to determine how EM changes as a function of particle charge and molecular mass, and how the molecular distribution changes due to surface modifications. We demonstrate that partially modified dendrimers have much broader migration peaks than those of fully surface functionalized or unmodified E5 dendrimers due to variations in the substitution of individual dendrimer surfaces. EM decreased nonlinearly with increases in surface acetylation for both PAMAM acetamides and PAMAM succinamic acids, indicating a complex migration activity in CE separations that is not solely due to charge/mass ratio changes. These studies provide new insights into dendrimer properties under an electric field, as well as into the characterization of dendrimer-based materials being developed for medical applications. | en_US |
dc.format.extent | 387703 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Biochemistry and Biotechnology | en_US |
dc.title | Electrophoretic mobility and molecular distribution studies of poly(amidoamine) dendrimers of defined charges | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI, USA ; Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA Fax: +1-734-936-2990 | en_US |
dc.contributor.affiliationother | Department of Physical Chemistry, University of Debrecen, Debrecen, Hungary | en_US |
dc.identifier.pmid | 16586414 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50647/1/1758_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/elps.200500818 | en_US |
dc.identifier.source | Electrophoresis | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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