Transplantation of hNT neurons into the ischemic cortex: Cell survival and effect on sensorimotor behavior
dc.contributor.author | Bliss, T. M. | en_US |
dc.contributor.author | Kelly, S. | en_US |
dc.contributor.author | Shah, A. K. | en_US |
dc.contributor.author | Foo, W. C. | en_US |
dc.contributor.author | Kohli, P. | en_US |
dc.contributor.author | Stokes, C. | en_US |
dc.contributor.author | Sun, G. H. | en_US |
dc.contributor.author | Ma, M. | en_US |
dc.contributor.author | Masel, J. | en_US |
dc.contributor.author | Kleppner, S. R. | en_US |
dc.contributor.author | Schallert, Timothy | en_US |
dc.contributor.author | Palmer, T. | en_US |
dc.contributor.author | Steinberg, G. K. | en_US |
dc.date.accessioned | 2007-05-02T14:16:24Z | |
dc.date.available | 2007-05-02T14:16:24Z | |
dc.date.issued | 2006-05-01 | en_US |
dc.identifier.citation | Bliss, T.M.; Kelly, S.; Shah, A.K.; Foo, W.C.; Kohli, P.; Stokes, C.; Sun, G.H.; Ma, M.; Masel, J.; Kleppner, S.R.; Schallert, T.; Palmer, T.; Steinberg, G.K. (2006). "Transplantation of hNT neurons into the ischemic cortex: Cell survival and effect on sensorimotor behavior." Journal of Neuroscience Research 83(6): 1004-1014. <http://hdl.handle.net/2027.42/50652> | en_US |
dc.identifier.issn | 0360-4012 | en_US |
dc.identifier.issn | 1097-4547 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50652 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16496370&dopt=citation | en_US |
dc.description.abstract | Cell transplantation offers a potential new treatment for stroke. Animal studies using models that produce ischemic damage in both the striatum and the frontal cortex have shown beneficial effects when hNT cells (postmitotic immature neurons) were transplanted into the ischemic striatum. In this study, we investigated the effect of hNT cells in a model of stroke in which the striatum remains intact and damage is restricted to the cortex. hNT cells were transplanted into the ischemic cortex 1 week after stroke induced by distal middle cerebral artery occlusion (dMCAo). The cells exhibited robust survival at 4 weeks posttransplant even at the lesion border. hNT cells did not migrate, but they did extend long neurites into the surrounding parenchyma mainly through the white matter. Neurite extension was predominantly toward the lesion in ischemic animals but was bidirectional in uninjured animals. Extension of neurites through the cortex toward the lesion was also seen when there was some surviving cortical tissue between the graft and the infarct. Prolonged deficits were obtained in four tests of sensory-motor function. hNT-transplanted animals showed a significant improvement in functional recovery on one motor test, but there was no effect on the other three tests relative to control animals. Thus, despite clear evidence of graft survival and neurite extension, the functional benefit of hNT cells after ischemia is not guaranteed. Functional benefit could depend on other variables, such as infarct location, whether the cells mature, the behavioral tests employed, rehabilitation training, or as yet unidentified factors. © 2006 Wiley-Liss, Inc. | en_US |
dc.format.extent | 673459 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Transplantation of hNT neurons into the ischemic cortex: Cell survival and effect on sensorimotor behavior | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology and Neurobiology, University of Texas at Austin, Texas ; Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, Stanford University, Stanford, California ; The first two authors contributed equally to this work. ; MSLS Bldg. p308, 1201 Welch Rd., Stanford, CA 94305 | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, Stanford University, Stanford, California | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, Stanford University, Stanford, California | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, Stanford University, Stanford, California | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, Stanford University, Stanford, California | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, Stanford University, Stanford, California | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, Stanford University, Stanford, California | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, Stanford University, Stanford, California | en_US |
dc.contributor.affiliationother | Department of Biological Sciences, Stanford University, Stanford, California | en_US |
dc.contributor.affiliationother | Layton BioScience, Sunnyvale, California | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, Stanford University, Stanford, California | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, Stanford University, Stanford, California ; Department of Neurology, Stanford University, Stanford, California | en_US |
dc.identifier.pmid | 16496370 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50652/1/20800_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jnr.20800 | en_US |
dc.identifier.source | Journal of Neuroscience Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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