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Interaction of Brain Noradrenergic System and the Hypothalamic-Pituitary-Adrenal (HPA) Axis in Man

dc.contributor.authorYoung, Elizabeth A.
dc.contributor.authorAbelson, James L.
dc.contributor.authorCameron, Oliver G.
dc.date.accessioned2007-05-15T16:47:05Z
dc.date.available2007-05-15T16:47:05Z
dc.date.issued2005-09-30
dc.identifier.citationPsychoneuroendocrinology 30:807-14, 2005 <http://hdl.handle.net/2027.42/51372>en
dc.identifier.urihttps://hdl.handle.net/2027.42/51372
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15896919&dopt=citationen_US
dc.description.abstractBackground: Numerous interactions between the brainstem locus coeruleus system and the HPA axis have been shown in experimental animals. This relationship is less well characterized in humans and little is known about the influence of psychiatric disorders, which disturb one of these systems, on this relationship. Methods: Untreated subjects with pure MDD (n=13), MDD with comorbid anxiety disorders (n=17), and pure anxiety disorders (n=15) were recruited by advertising. Age and sex matched control subjects were recruited for each subject with a psychiatric diagnosis (n=45). All subjects underwent a social stressor, the Trier Social Stress Test (TSST), and blood was collected for ACTH assay. These same subjects also underwent a clonidine challenge study for assessment of growth hormone release as a marker of tonic noradrenergic activation. Results: Examining log transformed area under the curve response for each hormone, a significant negative relationship (simple regression) was observed between systems in normal subjects. This relationship was preserved in anxiety subjects. However, both pure depressed and comorbid depressed and anxiety subjects demonstrated disruption of this relationship. Conclusions: Under normal circumstances, noradrenergic systems can influence the magnitude of the HPA axis response to stress. However, in subjects with major depression, HPA axis activation appears autonomous of noradrenergic influence.en
dc.description.sponsorshipNIMH MH57751 (all authors), MH 01931 to EAY, MO1 RR00042 (General Clinical Research Center (G-CRC) of the University of Michigan),en
dc.format.extent147680 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen
dc.publisherElsevieren
dc.subjectACTHen
dc.subjectCortisolen
dc.subjectGrowth Hormoneen
dc.subjectClonidineen
dc.titleInteraction of Brain Noradrenergic System and the Hypothalamic-Pituitary-Adrenal (HPA) Axis in Manen
dc.typeArticleen
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biology
dc.subject.hlbsecondlevelNeurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Revieweden
dc.contributor.affiliationumMBNIen
dc.contributor.affiliationumPsychiatryen
dc.contributor.affiliationumcampusAnn Arboren
dc.identifier.pmid15896919
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/51372/1/Youngintercation.pdfen_US
dc.identifier.sourcePsychoneuroendocrinologyen_US
dc.owningcollnameMolecular and Behavioral Neurosciences Institute


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