Impact of estrogen receptor expression and other clinicopathologic features on tamoxifen use in ductal carcinoma in situ
dc.contributor.author | Hird, R. Barry | en_US |
dc.contributor.author | Chang, Alfred E | en_US |
dc.contributor.author | Cimmino, Vincent M. | en_US |
dc.contributor.author | Diehl, Kathleen A. | en_US |
dc.contributor.author | Sabel, Michael S. | en_US |
dc.contributor.author | Kleer, Celina | en_US |
dc.contributor.author | Helvie, Mark A. | en_US |
dc.contributor.author | Schott, Anne F. | en_US |
dc.contributor.author | Young, Jennifer | en_US |
dc.contributor.author | Hayes, Daniel F. | en_US |
dc.contributor.author | Newman, Lisa A. | en_US |
dc.date.accessioned | 2007-07-11T18:13:39Z | |
dc.date.available | 2007-07-11T18:13:39Z | |
dc.date.issued | 2006-05-15 | en_US |
dc.identifier.citation | Hird, R. Barry; Chang, Alfred; Cimmino, Vincent; Diehl, Kathleen; Sabel, Michael; Kleer, Celina; Helvie, Mark; Schott, Anne; Young, Jennifer; Hayes, Daniel; Newman, Lisa (2006). "Impact of estrogen receptor expression and other clinicopathologic features on tamoxifen use in ductal carcinoma in situ." Cancer 106(10): 2113-2118. <http://hdl.handle.net/2027.42/55220> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/55220 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16596655&dopt=citation | en_US |
dc.description.abstract | BACKGROUND Recent data have demonstrated that benefit from adjuvant tamoxifen therapy for patients with ductal carcinoma in situ (DCIS) is limited to estrogen receptor (ER)-positive lesions. The objective of the current study was to correlate clinicopathologic features of DCIS with ER expression and the impact of this information on tamoxifen counseling. METHODS Women with DCIS who were treated from 2001 to 2004 were evaluated. Routine ER staining was initiated in January 2003. RESULTS Ninety-four women (mean age, 57.6 years) were analyzed. The mean DCIS size was 0.98 cm. ER-staining was performed in 55 lesions, and 76% were ER-positive. All Grade 1 and 2 DCIS lesions were ER-positive, compared with 54% of high-grade lesions ( P <.001); no other clinicopathologic feature significantly predicted ER status. Overall, 58 patients (62%) were offered tamoxifen, and the rates were similar for the pre-ER and post-ER staining periods. In the pre-ER staining period, surgical treatment and grade were associated with offering tamoxifen (75% of patients who underwent breast conservation vs. 40% of patients who underwent mastectomy; P = .03; 78% of patients with Grade 1 or 2 lesions vs. 45% of patients with Grade 3 lesions; P = .04). In the post-ER staining period, however, only ER status was correlated significantly with offering tamoxifen (71% of patients with ER-positive lesions vs. 31% of patients with ER-negative lesions; P = .01). Approximately 66% of patients who were offered tamoxifen agreed to treatment (approximately 33% of the total DCIS study sample). No clinicopathologic features predicted for tamoxifen acceptance by patients in either the pre-ER or post-ER staining periods. CONCLUSIONS Seventy-five percent of DCIS lesions were ER-positive. ER staining significantly influenced the likelihood that clinicians would offer tamoxifen to patients with DCIS, but it had no impact on whether patients accepted treatment. Cancer 2006. © 2006 American Cancer Society. | en_US |
dc.format.extent | 85867 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Impact of estrogen receptor expression and other clinicopathologic features on tamoxifen use in ductal carcinoma in situ | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Surgical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Division of Surgical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Division of Surgical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Division of Surgical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Division of Surgical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Medical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Division of Surgical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Medical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Division of Surgical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan ; Fax: (734) 647-9647 ; Division of Surgical Oncology, 3308 Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI, 48109 | en_US |
dc.identifier.pmid | 16596655 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/55220/1/21873_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/cncr.21873 | en_US |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.