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dc.contributor.authorKwok, Roland P. S.en_US
dc.contributor.authorLiu, Xiao-Tieen_US
dc.contributor.authorSmith, Gary D.en_US
dc.date.accessioned2007-07-11T18:17:16Z
dc.date.available2007-07-11T18:17:16Z
dc.date.issued2006-07en_US
dc.identifier.citationKwok, Roland P.S.; Liu, Xiao-Tie; Smith, Gary D. (2006). "Distribution of co-activators CBP and p300 during mouse oocyte and embryo development." Molecular Reproduction and Development 73(7): 885-894. <http://hdl.handle.net/2027.42/55243>en_US
dc.identifier.issn1040-452Xen_US
dc.identifier.issn1098-2795en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/55243
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16596650&dopt=citationen_US
dc.description.abstractcAMP response element binding protein (CREB)-binding protein (CBP) and p300 are two structurally related transcriptional co-activators that activate expression of many eukaryotic genes. Current dogma would suggest that these transcriptional co-activators have similar mechanisms of transcription regulation. Studies of CBP or p300 homozygotic mouse mutants indicate that normal embryogenesis requires the existence of both factors. However, whether this is indicative of a dosage effect of these two proteins, or whether these proteins play different roles in mouse embryo development is not clear. Here we demonstrated that both factors are first found in the cytoplasm of oocytes within primordial follicles, and that they enter into the oocyte nucleus at different stages of oocyte growth, suggesting that they may play different roles in gene expression during oocyte growth and development. Consistent with this model, in the pre-implantation mouse embryos, from the two-cell stage to the blastocyst stage, the localizations of CBP and p300 are different, at times opposite, indicating that CBP and p300 also have different functions in early mouse embryogenesis. Mol. Reprod. Dev. © 2006 Wiley-Liss, Inc.en_US
dc.format.extent487956 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleDistribution of co-activators CBP and p300 during mouse oocyte and embryo developmenten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelObstetrics and Gynecologyen_US
dc.subject.hlbsecondlevelWomen's and Gender Studiesen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelKinesiology and Sportsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelHumanitiesen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan ; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan ; Reproductive Science Program, University of Michigan, Ann Arbor, Michigan ; 6428 Medical Science I, 1301 E. Catherine Street, Ann Arbor, MI 48109.en_US
dc.contributor.affiliationumDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan ; Department of Physiology, University of Michigan, Ann Arbor, Michigan ; Reproductive Science Program, University of Michigan, Ann Arbor, Michigan ; 6428 Medical Science I, 1301 E. Catherine Street, Ann Arbor, MI 48109.en_US
dc.identifier.pmid16596650en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/55243/1/20440_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/mrd.20440en_US
dc.identifier.sourceMolecular Reproduction and Developmenten_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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