Now showing items 11-18 of 18
Increased recombination adjacent to the Huntington disease-linked D4S10 marker
(Elsevier, 1991-01)
Huntington disease (HD) is caused by a genetic defect distal to the anonymous DNA marker D4S10 in the terminal cytogenetic subband of the short arm of chromosome 4 (4p16.3). The effort to identify new markers linked to HD ...
Radiation hybrid map spanning the huntington disease gene region of chromosome 4Radiation hybrid map spanning the huntington disease gene region of chromosome 4
(Elsevier, 1992-08)
Radiation hybrid (RH) mapping was used to construct a map of 11 markers in the distal 4 Mb of the short arm of chromosome 4, the region containing the Huntington disease gene. Two different methods for deriving the order ...
Commingling and segregation analyses: Comparison of results from a simulation study of a quantitative trait
(Wiley Subscription Services, Inc., A Wiley Company, 1990)
Commingling analysis is commonly used to provide preliminary evidence for a single genetic locus with a major effect on the quantitative trait of interest. In this paper, the effectiveness of commingling analysis as a ...
A radiation hybrid map of the region on human chromosome 22 containing the neurofibromatosis type 2 locus
(Elsevier, 1992-11)
We describe a high-resolution radiation hybrid map of the region on human chromosome 22 containing the neurofibromatosis type 2 (NF2) gene. Eighty-five hamster--human somatic cell hybrids generated by X-irradiation and ...
Physical mapping of the nail patella syndrome interval at 9q34: ordering of STSs and ESTs
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1998-11)
The murine situs inversus viscerum (iv) gene responsible for visceral asymmetry is linked tightly to the Igh-C cluster on chromosome 12
(Elsevier, 1990-07)
The iv gene controls left-right determination during murine organogenesis. To map this gene, we analyzed backcross progeny produced by mating (C57BL/6J x MEV/Ty)F1-iv/+ heterozygotes to C57BL/6J-iv homozygotes. Hybridization ...
Integrated Mapping Analysis of the Werner Syndrome Region of Chromosome 8
(Elsevier, 1994-09-01)
The Werner syndrome locus (WRN) is located at 8p11-p12. To facilitate eventual cloning of the WRN gene, a 10,000-rad radiation-reduced hybrid (RH) cell panel was generated to map genetic markers, sequence-tagged sites ...
Affected-sib-pair interval mapping and exclusion for complex genetic traits: Sampling considerations
(Wiley Subscription Services, Inc., A Wiley Company, 1996)
We describe an extension of Risch's [(1990a,b) Am J Hum Genet 46:222–228, 229–241] method of linkage detection and exclusion for complex genetic traits. The method uses interval mapping to infer disease locus identity-by-descent ...