Now showing items 11-17 of 17
Nonparametric methods for analyzing replication origins in genomewide data
(Springer-Verlag, 2005-01)
Due to the advent of high-throughput genomic technology, it has become possible to monitor cellular activities on a genomewide basis. With these new methods, scientists can begin to address important biological questions. ...
Statistical issues and methods for meta-analysis of microarray data: a case study in prostate cancer
(Springer-Verlag, 2003-12)
With the proliferation of related microarray studies by independent groups, a natural step in the analysis of these gene expression data is to combine the results across these studies. However, this raises a variety of ...
Exploring the Public Understanding of Basic Genetic Concepts
(Kluwer Academic Publishers-Plenum Publishers; National Society of Genetic Counselors, Inc. ; Springer Science+Business Media, 2004-08)
It is predicted that the rapid acquisition of new genetic knowledge and related applications during the next decade will have significant implications for virtually all members of society. Currently, most people get exposed ...
Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands
(Wiley Subscription Services, Inc., A Wiley Company, 2002-07-08)
The goal of this study was to identify chromosomal regions likely to contain susceptibility alleles for early-onset obsessive-compulsive disorder (OCD). A genome scan was done in 56 individuals from seven families ascertained ...
A locus for posterior polymorphous corneal dystrophy ( PPCD3 ) maps to chromosome 10
(Wiley Subscription Services, Inc., A Wiley Company, 2004-11-01)
Posterior polymorphous corneal dystrophy (PPCD) is an autosomal dominant disorder characterized by corneal endothelial abnormalities, which can lead to blindness due to loss of corneal transparency and sometimes glaucoma. ...
Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database
(Wiley Subscription Services, Inc., A Wiley Company, 2006-02)
The pattern and nature of linkage disequilibrium in the human genome is being studied and catalogued as part of the International HapMap Project [:2003 Nature 426:789–796]. A key goal of the HapMap Project is to enable ...
Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large veterans affairs cooperative study sample
(Wiley Subscription Services, Inc., A Wiley Company, 2003-04-01)
Wei and Hemmings [2000: Nat Genet 25:376–377], using 80 British parent–offspring trios, identified a number of NOTCH4 variants and haplotypes that showed statistically significant evidence of association to schizophrenia. ...