Now showing items 11-20 of 41
Detection of oxidative mutagens in an urban air-particulate extract: a preliminary study
(Elsevier, 1992-12)
The Ames assays strains TA98 and TA100 have been useful in characterizing complex mixtures from organic solvent extracts of particles from diesel-powered vehicles, ambient air, and other sources. In this paper we report ...
Lod scores for gene mapping in the presence of marker map uncertainty
(John Wiley & Sons, Inc., 2001-07)
Multipoint lod scores are typically calculated for a grid of locus positions, moving the putative disease locus across a fixed map of genetic markers. Changing the order of a set of markers and/or the distances between the ...
Assessment of sex-specific genetic and environmental effects on bone mineral density
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09)
Although it is widely accepted that genes contribute significantly to the variation in bone mineral density (BMD), the nature of the genetic contribution is poorly defined. There are large gender differences in BMD, although ...
An evaluation of the replicate pool method: quick estimation of genome-wide linkage peak p -values
(Wiley Subscription Services, Inc., A Wiley Company, 2006-05)
The calculation of empirical p -values for genome-wide non-parametric linkage tests continues to present significant computational challenges for many complex disease mapping studies. The gold standard approach is to use ...
Novel mutations in XLRS1 causing retinoschisis, including first evidence of putative leader sequence change
(John Wiley & Sons, Inc., 1999-11)
Juvenile retinoschisis is an X-linked recessive disease caused by mutations in the XLRS1 gene. We screened 31 new unrelated patients and families for XLRS1 mutations in addition to previously reported mutations for 60 of ...
Synergism of mutant frequencies in the mouse lymphoma cell mutagenicity assay by binary mixtures of methyl methanesulfonate and ethyl methanesulfonate
(Elsevier, 1988-10)
The effect of mixed mutagen exposures on the rate and type of induced mutants was studied in the L5178Y/TK+/- --> TK-/- mouse lymphoma cell mutagenicity assay. In this assay, exposure to ethyl methanesulfonate (EMS) ...
Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns
(Springer-Verlag, 2005-11)
Mitochondria play an integral role in ATP production in cells and are involved in glucose metabolism and insulin secretion, suggesting that variants in the mitochondrial genome may contribute to diabetes susceptibility. ...
Nonparametric methods for analyzing replication origins in genomewide data
(Springer-Verlag, 2005-01)
Due to the advent of high-throughput genomic technology, it has become possible to monitor cellular activities on a genomewide basis. With these new methods, scientists can begin to address important biological questions. ...
Alternative genetic models for the inheritance of the phenylthiocarbamide taste deficiency
(Wiley Subscription Services, Inc., A Wiley Company, 1989)
Pedigree segregation analysis was used to examine several one- and two-locus models of the inheritance of phenylthiocarbamide (PTC) taste deficiency that extend the traditional one-locus recessive model by the addition of ...
A Radiation Hybrid Map of the BRCA1 Region of Chromosome 17q12-q21
(Elsevier, 1993-09)
The chromosomal region 17q12-q21 contains a gene (BRCA1) conferring susceptibility to early-onset familial breast and ovarian cancer. An 8000-rad radiation-reduced hybrid (RH) panel was constructed to provide a resource ...