Now showing items 21-30 of 44
Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus
(Springer-Verlag; Springer Science+Business Media, Inc., 2006-01)
Two related genes with potentially similar functions, one on the Y chromosome and one on the X chromosome, were examined to determine if they evolved differently because of their chromosomal positions. Six hundred fifty-seven ...
Alternative genetic models for the inheritance of the phenylthiocarbamide taste deficiency
(Wiley Subscription Services, Inc., A Wiley Company, 1989)
Pedigree segregation analysis was used to examine several one- and two-locus models of the inheritance of phenylthiocarbamide (PTC) taste deficiency that extend the traditional one-locus recessive model by the addition of ...
Racial differences in bumetanide-sensitive cotransport and N-ethylmaleimide-stimulated potassium efflux
(Elsevier, 1985-05-13)
Racial differences in erythrocyte potassium effluxes mediated by two loop-diuretic sensitive modes of cotransport were compared. In red cells loaded to contain approximately equimolar amounts of sodium and potassium, black ...
Expression of Pax2 and patterning of the chick inner ear
(Kluwer Academic Publishers; Springer Science+Business Media, 1999-10)
Early regionalized gene expression patterns within the otocyst appear to correlate with and contribute to development of mature otic structures. In the chick, the transcription factor Pax2 becomes restricted to the dorsal ...
A Radiation Hybrid Map of the BRCA1 Region of Chromosome 17q12-q21
(Elsevier, 1993-09)
The chromosomal region 17q12-q21 contains a gene (BRCA1) conferring susceptibility to early-onset familial breast and ovarian cancer. An 8000-rad radiation-reduced hybrid (RH) panel was constructed to provide a resource ...
Multipoint Radiation Hybrid Mapping: Comparison of Methods, Sample Size Requirements, and Optimal Study Characteristics
(Elsevier, 1994-05-01)
There are several statistical methods available for analyzing radiation hybrid (RH) data, but little is known about the ordering accuracy we can expect under common study conditions. Using analytic methods and computer ...
Multicolor FISH Mapping with Alu-PCR-Amplified YAC Clone DNA Determines the Order of Markers in the BRCA1 Region on Chromosome 17q12-q21
(Elsevier, 1993-09)
A gene designated BRCA1, implicated in the susceptibility to early-onset familial breast cancer, has recently been localized to chromosome 17q12-q21. To date, the order of DNA markers mapped within this region has been ...
Recombination fraction estimate of zero in the presence of apparent recombinants: Effects of incomplete penetrance and sporadic cases
(Wiley Subscription Services, Inc., A Wiley Company, 1995)
For a fully penetrant trait, apparent recombinants between the trait and marker loci result in an estimate of the recombination fraction θ > 0. Given allowance for reduced penetrance and/or sporadic cases, this no longer ...
The Atp1b3 gene for Na,K-ATPase β 3 subunit maps to mouse Chromosome 9, and a related gene, Atp1b3-rs, maps to mouse Chromosome 3
(Springer-Verlag; Springer-Verlag New York Inc., 1998-02)
Increased recombination adjacent to the Huntington disease-linked D4S10 marker
(Elsevier, 1991-01)
Huntington disease (HD) is caused by a genetic defect distal to the anonymous DNA marker D4S10 in the terminal cytogenetic subband of the short arm of chromosome 4 (4p16.3). The effort to identify new markers linked to HD ...