Now showing items 21-30 of 41
Statistical issues and methods for meta-analysis of microarray data: a case study in prostate cancer
(Springer-Verlag, 2003-12)
With the proliferation of related microarray studies by independent groups, a natural step in the analysis of these gene expression data is to combine the results across these studies. However, this raises a variety of ...
Multipoint Radiation Hybrid Mapping: Comparison of Methods, Sample Size Requirements, and Optimal Study Characteristics
(Elsevier, 1994-05-01)
There are several statistical methods available for analyzing radiation hybrid (RH) data, but little is known about the ordering accuracy we can expect under common study conditions. Using analytic methods and computer ...
Exploring the Public Understanding of Basic Genetic Concepts
(Kluwer Academic Publishers-Plenum Publishers; National Society of Genetic Counselors, Inc. ; Springer Science+Business Media, 2004-08)
It is predicted that the rapid acquisition of new genetic knowledge and related applications during the next decade will have significant implications for virtually all members of society. Currently, most people get exposed ...
Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands
(Wiley Subscription Services, Inc., A Wiley Company, 2002-07-08)
The goal of this study was to identify chromosomal regions likely to contain susceptibility alleles for early-onset obsessive-compulsive disorder (OCD). A genome scan was done in 56 individuals from seven families ascertained ...
Multicolor FISH Mapping with Alu-PCR-Amplified YAC Clone DNA Determines the Order of Markers in the BRCA1 Region on Chromosome 17q12-q21
(Elsevier, 1993-09)
A gene designated BRCA1, implicated in the susceptibility to early-onset familial breast cancer, has recently been localized to chromosome 17q12-q21. To date, the order of DNA markers mapped within this region has been ...
Recombination fraction estimate of zero in the presence of apparent recombinants: Effects of incomplete penetrance and sporadic cases
(Wiley Subscription Services, Inc., A Wiley Company, 1995)
For a fully penetrant trait, apparent recombinants between the trait and marker loci result in an estimate of the recombination fraction θ > 0. Given allowance for reduced penetrance and/or sporadic cases, this no longer ...
A locus for posterior polymorphous corneal dystrophy ( PPCD3 ) maps to chromosome 10
(Wiley Subscription Services, Inc., A Wiley Company, 2004-11-01)
Posterior polymorphous corneal dystrophy (PPCD) is an autosomal dominant disorder characterized by corneal endothelial abnormalities, which can lead to blindness due to loss of corneal transparency and sometimes glaucoma. ...
Increased recombination adjacent to the Huntington disease-linked D4S10 marker
(Elsevier, 1991-01)
Huntington disease (HD) is caused by a genetic defect distal to the anonymous DNA marker D4S10 in the terminal cytogenetic subband of the short arm of chromosome 4 (4p16.3). The effort to identify new markers linked to HD ...
Radiation hybrid map spanning the huntington disease gene region of chromosome 4Radiation hybrid map spanning the huntington disease gene region of chromosome 4
(Elsevier, 1992-08)
Radiation hybrid (RH) mapping was used to construct a map of 11 markers in the distal 4 Mb of the short arm of chromosome 4, the region containing the Huntington disease gene. Two different methods for deriving the order ...
Linkage analysis of von Recklinghausen neurofibromatosis to DNA markers on chromosome 17
(Elsevier, 1987-12)
Several recent studies indicate that the von Recklinghausen neurofibromatosis (NF1) gene is located near the centromere of chromosome 17 in some families. However, variable expressivity and a very high mutation rate suggest ...