Now showing items 91-94 of 94
Affected-sib-pair interval mapping and exclusion for complex genetic traits: Sampling considerations
(Wiley Subscription Services, Inc., A Wiley Company, 1996)
We describe an extension of Risch's [(1990a,b) Am J Hum Genet 46:222–228, 229–241] method of linkage detection and exclusion for complex genetic traits. The method uses interval mapping to infer disease locus identity-by-descent ...
MACF1 gene structure: a hybrid of plectin and dystrophin
(Springer-Verlag; Springer-Verlag New York Inc., 2001-11)
Mammalian MACF1 (Macrophin1; previously named ACF7) is a giant cytoskeletal linker protein with three known isoforms that arise by alternative splicing. We isolated a 19.1-kb cDNA encoding a fourth isoform (MACF1-4) with ...
Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large veterans affairs cooperative study sample
(Wiley Subscription Services, Inc., A Wiley Company, 2003-04-01)
Wei and Hemmings [2000: Nat Genet 25:376–377], using 80 British parent–offspring trios, identified a number of NOTCH4 variants and haplotypes that showed statistically significant evidence of association to schizophrenia. ...
Simulating the Allocation of Organs for Transplantation
(Kluwer Academic Publishers; Springer Science+Business Media, 2004-11)
The demand for donated organs greatly exceeds supply and many candidates die awaiting transplantation. Policies for allocating deceased donor organs may address equity of access and medical efficacy, but typically must be ...