Now showing items 1-10 of 17
Using sex-averaged genetic maps in multipoint linkage analysis when identity-by-descent status is incompletely known
(Wiley Subscription Services, Inc., A Wiley Company, 2006-07)
The ratio of male and female genetic map distances varies dramatically across the human genome. Despite these sex differences in genetic map distances, most multipoint linkage analyses use sex-averaged genetic maps. We ...
Resampling methods for variance estimation of singular value decomposition analyses from microarray experiments
(Springer-Verlag, 2002-08)
Microarray experiments offer the ability to generate gene expression measurements for thousands of genes simultaneously. Work has begun recently on attempting to reconstruct genetic networks based on analyses of microarray ...
Haplotype association analysis for late onset diseases using nuclear family data
(Wiley Subscription Services, Inc., A Wiley Company, 2006-04)
In haplotype-based association studies for late onset diseases, one attractive design is to use available unaffected spouses as controls (Valle et al. [1998] Diab. Care 21:949–958). Given cases and spouses only, the standard ...
Covariate adjustment in the analysis of microarray data from clinical studies
(Springer-Verlag, 2005-01)
There is tremendous scientific interest in the analysis of gene expression data in clinical settings, such as oncology. In this paper, we describe the importance of adjusting for confounders and other prognostic factors ...
Genetic counseling for BRCA1 / 2 : A randomized controlled trial of two strategies to facilitate the education and counseling process This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/1552–4825/suppmat/index.html .
(Wiley Subscription Services, Inc., A Wiley Company, 2005-04-01)
Due to the complexity of information surrounding BRCA1 / 2 counseling and testing and its time consuming nature, efforts to facilitate the genetic counseling and education process are needed. Using a 2 × 2 factorial ...
Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3–q27 are associated with development of esophageal adenocarcinoma
(Wiley Subscription Services, Inc., A Wiley Company, 2006-04)
Gene amplification is one of the mechanisms to activate oncogenes in many cancers, including esophageal adenocarcinoma (EA). In the present study, we used two-dimensional restriction landmark genome scanning to clone a ...
Lod scores for gene mapping in the presence of marker map uncertainty
(John Wiley & Sons, Inc., 2001-07)
Multipoint lod scores are typically calculated for a grid of locus positions, moving the putative disease locus across a fixed map of genetic markers. Changing the order of a set of markers and/or the distances between the ...
Assessment of sex-specific genetic and environmental effects on bone mineral density
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09)
Although it is widely accepted that genes contribute significantly to the variation in bone mineral density (BMD), the nature of the genetic contribution is poorly defined. There are large gender differences in BMD, although ...
An evaluation of the replicate pool method: quick estimation of genome-wide linkage peak p -values
(Wiley Subscription Services, Inc., A Wiley Company, 2006-05)
The calculation of empirical p -values for genome-wide non-parametric linkage tests continues to present significant computational challenges for many complex disease mapping studies. The gold standard approach is to use ...
Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns
(Springer-Verlag, 2005-11)
Mitochondria play an integral role in ATP production in cells and are involved in glucose metabolism and insulin secretion, suggesting that variants in the mitochondrial genome may contribute to diabetes susceptibility. ...