Now showing items 1-10 of 23
Non-parametric estimation of gap time survival functions for ordered multivariate failure time data
(John Wiley & Sons, Ltd., 2004-06-30)
Times between sequentially ordered events (gap times) are often of interest in biomedical studies. For example, in a cancer study, the gap times from incidence-to-remission and remission-to-recurrence may be examined. Such ...
A shared random effects model for censored medical costs and mortality
(John Wiley & Sons, Ltd., 2006)
In this paper, we propose a model for medical costs recorded at regular time intervals, e.g. every month, as repeated measures in the presence of a terminating event, such as death. Prior models have related monthly medical ...
Semiparametric inferences for association with semi-competing risks data
(John Wiley & Sons, Ltd., 2005)
In many biomedical studies, it is of interest to assess dependence between bivariate failure time data. We focus here on a special type of such data, referred to as semi-competing risks data. In this article, we develop ...
Estimation for paired binomial data with application to radiation therapy
(John Wiley & Sons, Ltd., 2001-11-30)
We compare and contrast several different methods for estimating the effect of treatment when responses are paired binomial observations. The ratio of binomial probabilities is the parameter of interest, while the binomial ...
A family study of obsessive-compulsive disorder with pediatric probands
(Wiley Subscription Services, Inc., A Wiley Company, 2005-04-05)
Obsessive-compulsive disorder (OCD) is a heterogeneous disorder of unknown etiology. We examined the lifetime history of obsessions, compulsions, and OCD in the first- and second-degree relatives of 35 pediatric probands ...
Stress and female reproductive function: A study of daily variations in cortisol, gonadotrophins, and gonadal steroids in a rural Mayan population
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09)
We report here on a longitudinal study of stress and women's reproduction in a small Kaqchikel Mayan community in rural Guatemala. Current understanding of the effects of stress on the reproductive axis in women is mostly ...
Generalizing the TITE-CRM to adapt for early- and late-onset toxicities
(John Wiley & Sons, Ltd., 2005)
Due to the staggered entry of subjects in phase I trials, some subjects will only be partially through the study when others are ready to be enrolled. Nonetheless, many phase I designs focus solely upon whether or not ...
Modelling tumour biology–progression relationships in screening trials
(John Wiley & Sons, Ltd., 2005)
There has been some recent work in the statistical literature for modelling the relationship between tumour biology properties and tumour progression in screening trials. While non-parametric methods have been proposed for ...
PTSD and depression after the Madrid March 11 train bombings
(Wiley Subscription Services, Inc., A Wiley Company, 2006-02)
The March 11, 2004, train bombings in Madrid, Spain, caused the largest loss of life from a single terrorist attack in modern European history. We used a cross-sectional random digit dial survey of Madrid residents to ...
Bias reduction for risk ratio and vaccine effect estimators
(John Wiley & Sons, Ltd., 2001-06-15)
We examine the structural bias for established estimators of vaccine effects on susceptibility and for newer estimates of vaccine effects on infectiousness. We then propose and analyse new bias corrections for vaccine ...