Now showing items 1-10 of 27
Decade-long bacterial community dynamics in cystic fibrosis airways
(2012-04-10)
The structure and dynamics of bacterial communities in the airways
of persons with cystic fibrosis (CF) remain largely unknown. We
characterized the bacterial communities in 126 sputum samples
representing serial ...
On Using Summary Statistics from an External Calibration Sample to Correct for Covariate Measurement Error
(2012)
Background: Covariate measurement error is common in epidemiologic studies. Current methods for correcting measurement error
with information from external calibration samples are insufficient to provide valid adjusted ...
Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease
(2012)
Background The value of quantitative CT (QCT) to
identify chronic obstructive pulmonary disease (COPD)
phenotypes is increasingly appreciated. The authors
hypothesised that QCT-defined emphysema and airway
abnormalities ...
Contributions of chaperone/usher systems to cell binding, biofilm formation and Yersinia pestis virulence
(2011)
Yersinia pestis genome sequencing projects have revealed six intact uncharacterized chaperone/
usher systems with the potential to play roles in plague pathogenesis. We cloned each locus and
expressed them in the Deltafim ...
Clinical Predictors of a Diagnosis of Idiopathic Pulmonary Fibrosis
(2010)
Rationale: Idiopathic pulmonary fibrosis (IPF) and other idiopathic
interstitial pneumonias (IIPs) have similar clinical and radiographic
features, but their histopathology, response to therapy, and natural
history ...
CURRICULUM VITAE - UPDATED
(2016-11-01)
This provides a update of my curriculum vitae from 2011 to 2016 (most recent five years)
Prevalence and Clinical Correlates of Bronchoreversibility in Severe Emphysema
(2010-05-01)
Chronic obstructive pulmonary disease (COPD) exhibits airflow obstruction that is
not fully reversible. The importance of bronchoreversibility remains controversial.
We hypothesised that an emphysematous phenotype of ...
Pulmonary function measures predict mortality differently in IPF versus combined pulmonary fibrosis and emphysema
(2011)
The composite physiologic index (CPI) was derived to represent the extent of
fibrosis on high-resolution computed tomography (HRCT), adjusting for emphysema in patients
with idiopathic pulmonary fibrosis (IPF). We ...
Cytotoxic potential of lung CD8+ T cells increases with COPD severity and with in vitro stimulation with IL-18 or IL-15
(2010)
Lung CD8+ T cells might contribute to progression of chronic obstructive pulmonary disease (COPD) indirectly via IFN-gamma
production or directly via cytolysis, but evidence for either mechanism is largely circumstantial. ...
Optimizing Inpatient Nutritional Care in Electronic Health Records
(2019-02-01)
As electronic health records (EHRs) become increasingly prevalent in healthcare, more can be done to optimize its utilization to serve patients’ needs. One major opportunity to improve comes in the form of better integrating ...