A phase II evaluation of a 3-hour infusion of paclitaxel, cisplatin, and 5-fluorouracil in patients with advanced or recurrent squamous cell carcinoma of the head and neck
dc.contributor.author | Worden, Francis P. | en_US |
dc.contributor.author | Moon, James | en_US |
dc.contributor.author | Samlowski, Wolfram E. | en_US |
dc.contributor.author | Clark, Joseph I. | en_US |
dc.contributor.author | Dakhil, Shaker R. | en_US |
dc.contributor.author | Williamson, Stephen | en_US |
dc.contributor.author | Urba, Susan G. | en_US |
dc.contributor.author | Ensley, John | en_US |
dc.contributor.author | Hussain, Maha H. A. | en_US |
dc.date.accessioned | 2007-09-18T19:18:01Z | |
dc.date.available | 2007-09-18T19:18:01Z | |
dc.date.issued | 2006-07-15 | en_US |
dc.identifier.citation | Worden, Francis P.; Moon, James; Samlowski, Wolfram; Clark, Joseph I.; Dakhil, Shaker R.; Williamson, Stephen; Urba, Susan G.; Ensley, John; Hussain, Maha H. (2006). "A phase II evaluation of a 3-hour infusion of paclitaxel, cisplatin, and 5-fluorouracil in patients with advanced or recurrent squamous cell carcinoma of the head and neck." Cancer 107(2): 319-327. <http://hdl.handle.net/2027.42/55775> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/55775 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16779801&dopt=citation | en_US |
dc.description.abstract | BACKGROUND. Previous data from an institutional pilot study in patients with advanced or recurrent squamous cell carcinoma of the head and neck (SCCHN) who received treated a combined chemotherapy regimen of paclitaxel, cisplatin, and 5-fluorouracil indicated an overall response rate of 60% and a median survival of 6 months. To validate these results and to determine the feasibility of this combination, a Phase II study was conducted by the Southwest Oncology Group (SWOG S0007). METHODS. Patients with advanced or recurrent SCCHN were eligible if they had received 1 previous regimen of induction/adjuvant chemotherapy or no prior systemic therapy. Patients received treatment with paclitaxel (135 mg/m 2 on Day 1), followed by cisplatin (75 mg/m 2 on Day 1), and 5-fluorouracil (1000 mg/m 2 per day as a 96-hour continuous infusion on Days 1–4) every 21 days. RESULTS. Seventy-six patients received a combined total of 286 cycles of chemotherapy. Sixty-nine patients were evaluable for response. There were 5 complete responses (7%) and 23 partial responses (33%) partial responses, for an overall response rate of 41%. The median progression-free survival was 4 months, and the median overall survival was 10 months. Six treatment-related deaths were documented, including deaths in 2 patients who had a Zubrod PS of 2. Grade 3 or 4 neutropenia (according to National Cancer Institute Common Toxicity Criteria [version 2.0]) was observed in 47% of patients. Other Grade 3 or 4 adverse events included mucositis (34% of patients), nausea (20% of patients), anemia (9% of patients), and neuropathy (8% of patients). CONCLUSIONS. The combination of paclitaxel, cisplatin, and 5-fluorouracil had efficacy similar to that of standard treatment regimens in patients with advanced or recurrent SCCHN but with increased toxicity. Cancer 2006. © 2006 American Cancer Society. | en_US |
dc.format.extent | 132046 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | A phase II evaluation of a 3-hour infusion of paclitaxel, cisplatin, and 5-fluorouracil in patients with advanced or recurrent squamous cell carcinoma of the head and neck | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Medical Oncology, University of Michigan, Ann Arbor, Michigan ; Fax: (734) 647-8792 ; Department of Hematology/Oncology, University of Michigan, 1500 E. Medical Center Drive, C361 MIB 0848, Ann Arbor, MI 48109-0848 | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Medical Oncology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Medical Oncology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, Division of Medical Oncology, Southwest Oncology Group Statistical Center, Seattle, Washington | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, Division of Medical Oncology, Wayne State University Medical Center, Detroit, Michigan | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, Division of Medical Oncology, Loyola University Stritch School of Medicine, Maywood, Illinois | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, Division of Medical Oncology, Wichita Community Clinical Oncology Program, Wichita, Kansas | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, Division of Medical Oncology, University of Kansas Medical Center, Kansas City, Missouri | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, Division of Medical Oncology, University of Utah Health Science Center, Salt Lake City, Utah | en_US |
dc.identifier.pmid | 16779801 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/55775/1/21994_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/cncr.21994 | en_US |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.