Dopamine receptor signaling molecules are altered in elderly schizophrenic cortex

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dc.contributor.author Baracskay, Karen L. en_US
dc.contributor.author Haroutunian, Vahram en_US
dc.contributor.author Meador-Woodruff, James H. en_US
dc.date.accessioned 2007-09-18T19:20:56Z
dc.date.available 2007-09-18T19:20:56Z
dc.date.issued 2006-09-15 en_US
dc.identifier.citation Baracskay, Karen L.; Haroutunian, Vahram; Meador-Woodruff, James H. (2006). "Dopamine receptor signaling molecules are altered in elderly schizophrenic cortex." Synapse 60(4): 271-279. <http://hdl.handle.net/2027.42/55792> en_US
dc.identifier.issn 0887-4476 en_US
dc.identifier.issn 1098-2396 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/55792
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16786528&dopt=citation en_US
dc.description.abstract Alterations of molecules that mediate dopaminergic signal transduction have been found in schizophrenia, supporting the hypothesis of altered dopaminergic neurotransmission in this illness. To further explore this hypothesis, the authors measured transcript expression of three proteins involved in dopamine (DA) signaling in postmortem dorsolateral prefrontal and anterior cingulate cortex of elderly schizophrenic subjects and a comparison group. The transcript encoding calcyon, a protein that potentiates crosstalk between D1 DA receptors and G q/11 -linked receptors, was increased in schizophrenic prefrontal and cingulate cortex by 25%. Transcript levels of spinophilin, a protein enriched in dendritic spines that modulates excitatory neurotransmission, were increased 22% in dorsolateral prefrontal cortex but were unchanged in anterior cingulate cortex in schizophrenia. Levels of DARPP-32 mRNA, a downstream effector of dopaminergic neurotransmission, were similar in both groups for both cortical groups. These alterations in spinophilin and calcyon mRNA levels in schizophrenic prefrontal and cingulate cortex provide further evidence of altered dopaminergic neurotransmission in this illness. Synapse 60:271–279, 2006. © 2006 Wiley-Liss, Inc. en_US
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dc.format.extent 3118 bytes
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dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Neuroscience, Neurology and Psychiatry en_US
dc.title Dopamine receptor signaling molecules are altered in elderly schizophrenic cortex en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbsecondlevel Neurosciences en_US
dc.subject.hlbsecondlevel Public Health en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.subject.hlbtoplevel Science en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan ; Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan en_US
dc.contributor.affiliationum Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan ; Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Psychiatry, University of Alabama at Birmingham SC 560C, 1530 3rd Ave. S, Birmingham, AL 35294-0017 en_US
dc.contributor.affiliationother Department of Psychiatry, Mount Sinai School of Medicine, New York, New York en_US
dc.identifier.pmid 16786528 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/55792/1/20292_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/syn.20292 en_US
dc.identifier.source Synapse en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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