Estimate of vascular permeability and cerebral blood volume using Gd-DTPA contrast enhancement and dynamic T2*-weighted MRI
dc.contributor.author | Cao, Yue | en_US |
dc.contributor.author | Shen, Zhen | en_US |
dc.contributor.author | Chenevert, Thomas L. | en_US |
dc.contributor.author | Ewing, James R. | en_US |
dc.date.accessioned | 2007-09-18T19:21:37Z | |
dc.date.available | 2007-09-18T19:21:37Z | |
dc.date.issued | 2006-08 | en_US |
dc.identifier.citation | Cao, Yue; Shen, Zhen; Chenevert, Thomas L.; Ewing, James R. (2006). "Estimate of vascular permeability and cerebral blood volume using Gd-DTPA contrast enhancement and dynamic T2*-weighted MRI." Journal of Magnetic Resonance Imaging 24(2): 288-296. <http://hdl.handle.net/2027.42/55796> | en_US |
dc.identifier.issn | 1053-1807 | en_US |
dc.identifier.issn | 1522-2586 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/55796 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16795091&dopt=citation | en_US |
dc.description.abstract | Purpose To develop a numerical approach for estimation of vascular permeability from dynamic T2*-weighted imaging, a technique routinely used to measure cerebral blood volume (CBV) and flow in gliomas. Materials and Methods This study describes a process for estimating both the gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) transvascular transfer constant and CBV from dynamic T2*-weighted images. The algorithm was applied to data from the brains of 12 patients with grade IV gliomas. The stability of the method was assessed. Estimates of CBV by this technique were compared to those of the conventional method. Results The algorithm was found to be insensitive to noise and to generate stable voxel-by-voxel estimates of permeability and CBV. Conclusion Using a single imaging acquisition, the three most important vascular properties, CBV, cerebral blood flow (CBF), and permeability, can be estimated. This approach may have potential in clinical evaluation of patients with brain tumor or acute ischemic stroke. J. Magn. Reson. Imaging 2006. © 2006 Wiley-Liss, Inc. | en_US |
dc.format.extent | 448137 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Imaging | en_US |
dc.title | Estimate of vascular permeability and cerebral blood volume using Gd-DTPA contrast enhancement and dynamic T2*-weighted MRI | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA ; Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA ; Department of Radiation Oncology, University of Michigan, 1500 E. Medical Center Drive, Rm. B2C438, Box 0010, Ann Arbor, MI 48109-0010 | en_US |
dc.contributor.affiliationum | Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Neurology, Henry Ford Health System, Detroit, Michigan, USA | en_US |
dc.identifier.pmid | 16795091 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/55796/1/20634_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jmri.20634 | en_US |
dc.identifier.source | Journal of Magnetic Resonance Imaging | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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