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dc.contributor.authorCao, Yueen_US
dc.contributor.authorShen, Zhenen_US
dc.contributor.authorChenevert, Thomas L.en_US
dc.contributor.authorEwing, James R.en_US
dc.date.accessioned2007-09-18T19:21:37Z
dc.date.available2007-09-18T19:21:37Z
dc.date.issued2006-08en_US
dc.identifier.citationCao, Yue; Shen, Zhen; Chenevert, Thomas L.; Ewing, James R. (2006). "Estimate of vascular permeability and cerebral blood volume using Gd-DTPA contrast enhancement and dynamic T2*-weighted MRI." Journal of Magnetic Resonance Imaging 24(2): 288-296. <http://hdl.handle.net/2027.42/55796>en_US
dc.identifier.issn1053-1807en_US
dc.identifier.issn1522-2586en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/55796
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16795091&dopt=citationen_US
dc.description.abstractPurpose To develop a numerical approach for estimation of vascular permeability from dynamic T2*-weighted imaging, a technique routinely used to measure cerebral blood volume (CBV) and flow in gliomas. Materials and Methods This study describes a process for estimating both the gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) transvascular transfer constant and CBV from dynamic T2*-weighted images. The algorithm was applied to data from the brains of 12 patients with grade IV gliomas. The stability of the method was assessed. Estimates of CBV by this technique were compared to those of the conventional method. Results The algorithm was found to be insensitive to noise and to generate stable voxel-by-voxel estimates of permeability and CBV. Conclusion Using a single imaging acquisition, the three most important vascular properties, CBV, cerebral blood flow (CBF), and permeability, can be estimated. This approach may have potential in clinical evaluation of patients with brain tumor or acute ischemic stroke. J. Magn. Reson. Imaging 2006. © 2006 Wiley-Liss, Inc.en_US
dc.format.extent448137 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherImagingen_US
dc.titleEstimate of vascular permeability and cerebral blood volume using Gd-DTPA contrast enhancement and dynamic T2*-weighted MRIen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA ; Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA ; Department of Radiation Oncology, University of Michigan, 1500 E. Medical Center Drive, Rm. B2C438, Box 0010, Ann Arbor, MI 48109-0010en_US
dc.contributor.affiliationumDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Henry Ford Health System, Detroit, Michigan, USAen_US
dc.identifier.pmid16795091en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/55796/1/20634_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/jmri.20634en_US
dc.identifier.sourceJournal of Magnetic Resonance Imagingen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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