Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia Presented in part at the 2005 American Society of Pediatric Hematology Oncology (ASPHO) Annual Meeting, May 14–17, 2005, Washington, DC.
dc.contributor.author | Gurney, James G. | en_US |
dc.contributor.author | Ness, Kirsten K. | en_US |
dc.contributor.author | Sibley, Shalamar D. | en_US |
dc.contributor.author | O'Leary, Maura | en_US |
dc.contributor.author | Dengel, Donald R. | en_US |
dc.contributor.author | Lee, Joyce M. | en_US |
dc.contributor.author | Youngren, Nancy M. | en_US |
dc.contributor.author | Glasser, Stephen P. | en_US |
dc.contributor.author | Baker, K. Scott | en_US |
dc.date.accessioned | 2007-09-18T19:24:06Z | |
dc.date.available | 2007-09-18T19:24:06Z | |
dc.date.issued | 2006-09-15 | en_US |
dc.identifier.citation | Gurney, James G.; Ness, Kirsten K.; Sibley, Shalamar D.; O'Leary, Maura; Dengel, Donald R.; Lee, Joyce M.; Youngren, Nancy M.; Glasser, Stephen P.; Baker, K. Scott (2006). "Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia Presented in part at the 2005 American Society of Pediatric Hematology Oncology (ASPHO) Annual Meeting, May 14–17, 2005, Washington, DC. ." Cancer 107(6): 1303-1312. <http://hdl.handle.net/2027.42/55810> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/55810 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16894525&dopt=citation | en_US |
dc.description.abstract | BACKGROUND. The purpose of the study was to determine the prevalence of metabolic syndrome, growth hormone deficiency, and cardiovascular risk factors among adult survivors of childhood acute lymphoblastic leukemia (ALL) treated with or without cranial irradiation. METHODS. Follow-up was undertaken of 75 randomly selected long-term childhood ALL survivors. Testing included fasting insulin, glucose, lipids, and growth hormone (GH) releasing hormone plus arginine stimulation test. The prevalence of metabolic syndrome was compared with population norms from 1999–2002 National Health and Nutrition Examination Study (NHANES) data, and internally between those with and without past cranial irradiation and those with normal (>16.5 Μg/L) versus insufficient (9–16.5 Μg/L) versus deficient (<9 Μg/L) peak GH secretion. RESULTS. The mean subject age was 30 years and the mean time since ALL diagnosis was 25 years. The prevalence of metabolic syndrome did not differ statistically ( P = .87) between study subjects (16.6%) and same-age, same-sex population norms (17.5%). However, 60% of subjects treated with cranial irradiation, compared with 20% of those who were not, had 2 or more of the 5 components of metabolic syndrome. Untreated abnormally low GH was present in 64% of subjects overall and 85% of those who received past cranial irradiation. Cranial irradiation was strongly related to GH deficiency, and in turn lower insulin-like growth factor 1 (IGF-1), higher fasting insulin, abdominal obesity, and dyslipidemia, particularly in women. CONCLUSIONS. Hematologists who treat childhood ALL patients, and particularly those who provide primary care to adult survivors, should be aware of the potential for long-term GH deficiency and adverse cardiovascular and diabetes risk profiles as a consequence of leukemia treatment. Cancer 2006. © 2006 American Cancer Society. | en_US |
dc.format.extent | 115590 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia Presented in part at the 2005 American Society of Pediatric Hematology Oncology (ASPHO) Annual Meeting, May 14–17, 2005, Washington, DC. | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Child Health Evaluation and Research (CHEAR) Unit, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan ; Fax: (734) 764-2599 ; Division of General Pediatrics, University of Michigan Medical School, 300 N. Ingalls St., Room 6E02, Ann Arbor, MI 48109-0456 | en_US |
dc.contributor.affiliationum | Child Health Evaluation and Research (CHEAR) Unit, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan ; Division of Pediatric Endocrinology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Division of Epidemiology & Clinical Research, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota | en_US |
dc.contributor.affiliationother | Division of Endocrinology, University of Minnesota Medical School, Minneapolis, Minnesota | en_US |
dc.contributor.affiliationother | Children's Oncology Group/Curesearch, Bethesda Maryland | en_US |
dc.contributor.affiliationother | School of Kinesiology, University of Minnesota, Minneapolis, Minnesota | en_US |
dc.contributor.affiliationother | Division of Epidemiology & Clinical Research, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota ; Division of Hematology/Oncology/Bone Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, Minnesota | en_US |
dc.contributor.affiliationother | Division of Preventive Medicine, University of Alabama-Birmingham Medical School, Birmingham, Alabama | en_US |
dc.contributor.affiliationother | Division of Hematology/Oncology/Bone Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, Minnesota | en_US |
dc.identifier.pmid | 16894525 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/55810/1/22120_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/cncr.22120 | en_US |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.