Modeling hepatic fibrosis in African American and Caucasian American patients with chronic hepatitis C virus infection
dc.contributor.author | Fontana, Robert John | en_US |
dc.contributor.author | Kleiner, David E. | en_US |
dc.contributor.author | Bilonick, Richard | en_US |
dc.contributor.author | Terrault, Norah A. | en_US |
dc.contributor.author | Afdhal, Nezam H. | en_US |
dc.contributor.author | Belle, Steven H. | en_US |
dc.contributor.author | Jeffers, Lennox J. | en_US |
dc.contributor.author | Ramcharran, Darmendra | en_US |
dc.contributor.author | Ghany, Marc G. | en_US |
dc.contributor.author | Hoofnagle, Jay H. | en_US |
dc.date.accessioned | 2007-09-20T17:42:36Z | |
dc.date.available | 2008-01-03T16:19:33Z | en_US |
dc.date.issued | 2006-10 | en_US |
dc.identifier.citation | Fontana, Robert J.; Kleiner, David E.; Bilonick, Richard; Terrault, Norah; Afdhal, Nezam; Belle, Steven H.; Jeffers, Lennox J.; Ramcharran, Darmendra; Ghany, Marc G.; Hoofnagle, Jay H. (2006). "Modeling hepatic fibrosis in African American and Caucasian American patients with chronic hepatitis C virus infection Members of Virahep-C contributing to the study are listed in the Acknowledgment section. Potential conflict of interest: Dr. Fontana is a consultant and is on the Speakers' Bureau for Roche. Dr. Jeffers is a consultant, advises, received grants, and is on the Speakers' Bureau for Roche. He received grants from Bristol Myers Squibb. He is on the Speakers' Bureau for Schering. Dr. Afdhal received grants from EchoSens and Quest. He is a consultant and received grants from Prometheus. Dr. Afdhal is a consultant for and received grants from Schering Plough. ." Hepatology 44(4): 925-935. <http://hdl.handle.net/2027.42/55833> | en_US |
dc.identifier.issn | 0270-9139 | en_US |
dc.identifier.issn | 1527-3350 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/55833 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17006909&dopt=citation | en_US |
dc.description.abstract | Assessment of histological stage is an integral part of disease management in patients infected with the hepatitis C virus (HCV). The aim of this study was to develop a model incorporating objective clinical and laboratory parameters to estimate the probability of severe fibrosis ( i.e. , Ishak fibrosis ≥ 3) in previously untreated African American (AA) and Caucasian American (CA) patients with HCV genotype 1. The Ishak fibrosis scores of 205 CA and 194 AA patients enrolled in the Viral Resistance to Antiviral Therapy of Chronic Hepatitis C study (Virahep-C) were modeled using simple and multiple logistic regression. The model was then validated in an independent cohort of 461 previously untreated patients with HCV. The distribution of fibrosis scores was similar in the AA and CA patients as was the proportion of patients with severe fibrosis (35% vs. 39%, P = .47). After accounting for the number of portal areas in the biopsy, patient age, serum aspartate aminotransferase, alkaline phosphatase, and platelet count were independently associated with severe fibrosis in the overall cohort, and the relationship with fibrosis was similar in both the AA and CA subgroups. The area under the receiver operating characteristic curve (AUROC) of the Virahep-C model (0.837) was significantly better than in other published models ( P = .0003). The AUROC of the Virahep-C model was 0.851 in the validation population. In conclusion , a model consisting of widely available clinical and laboratory features predicted severe hepatic fibrosis equally well in AA and CA patients with HCV genotype 1 and was superior to other published models. The excellent performance of the Virahep-C model in an external validation cohort suggests the findings are replicable and potentially generalizable. (H EPATOLOGY 2006;44:925–935.) | en_US |
dc.format.extent | 266163 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Hepatology | en_US |
dc.title | Modeling hepatic fibrosis in African American and Caucasian American patients with chronic hepatitis C virus infection | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan, Ann Arbor, MI ; fax: 734-936-7392 ; 3912 Taubman Center, Ann Arbor, MI 48109-0362 | en_US |
dc.contributor.affiliationother | National Cancer Institute, Bethesda, MD | en_US |
dc.contributor.affiliationother | University of Pittsburgh, Pittsburgh, PA | en_US |
dc.contributor.affiliationother | University of California San Francisco, San Francisco, CA | en_US |
dc.contributor.affiliationother | Beth Israel Deaconess Medical Center, Boston, MA | en_US |
dc.contributor.affiliationother | University of Pittsburgh, Pittsburgh, PA | en_US |
dc.contributor.affiliationother | University of Miami, Miami, FL | en_US |
dc.contributor.affiliationother | University of Pittsburgh, Pittsburgh, PA | en_US |
dc.contributor.affiliationother | National Institutes of Diabetes and Digestive and Kidney Diseases, Bethesda, MD | en_US |
dc.contributor.affiliationother | National Institutes of Diabetes and Digestive and Kidney Diseases, Bethesda, MD | en_US |
dc.identifier.pmid | 17006909 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/55833/1/21335_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/hep.21335 | en_US |
dc.identifier.source | Hepatology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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