Evaluation of semi-quantitative scoring system for metaiodobenzylguanidine (mIBG) scans in patients with relapsed neuroblastoma
dc.contributor.author | Messina, Julia A. | en_US |
dc.contributor.author | Cheng, Su-Chun | en_US |
dc.contributor.author | Franc, Benjamin L. | en_US |
dc.contributor.author | Charron, Martin | en_US |
dc.contributor.author | Shulkin, Barry L. | en_US |
dc.contributor.author | To, Bao | en_US |
dc.contributor.author | Maris, John M. | en_US |
dc.contributor.author | Yanik, Gregory A. | en_US |
dc.contributor.author | Hawkins, Randall A. | en_US |
dc.contributor.author | Matthay, Katherine K. | en_US |
dc.date.accessioned | 2007-09-20T17:46:17Z | |
dc.date.available | 2008-01-03T16:20:28Z | en_US |
dc.date.issued | 2006-12 | en_US |
dc.identifier.citation | Messina, Julia A.; Cheng, Su-Chun; Franc, Benjamin L.; Charron, Martin; Shulkin, Barry; To, Bao; Maris, John M.; Yanik, Gregory; Hawkins, Randall A.; Matthay, Katherine K. (2006). "Evaluation of semi-quantitative scoring system for metaiodobenzylguanidine (mIBG) scans in patients with relapsed neuroblastoma." Pediatric Blood & Cancer 47(7): 865-874. <http://hdl.handle.net/2027.42/55847> | en_US |
dc.identifier.issn | 1545-5009 | en_US |
dc.identifier.issn | 1545-5017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/55847 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16444675&dopt=citation | en_US |
dc.description.abstract | Background The purpose of this study was to determine the accuracy of two semi-quantitative scoring systems to assess response to 131 I-metaiodobenzylguanidine (mIBG) therapy in recurrent neuroblastoma. Procedures Diagnostic mIBG scan pairs (n = 57) were collected for patients who underwent 131 I-mIBG therapy for relapsed neuroblastoma. Two scoring systems were designated: Method 1, which divided the body into nine segments to view osteomedullary lesions with an additional tenth segment to assess soft tissue involvement; and Method 2, which divided the body into seven segments without a corresponding compartment for soft tissue involvement. Four nuclear medicine physicians independently assigned extension and intensity scores utilizing both methods, and separately recorded their impression of whether the post-therapy scan had improved, not changed, or worsened. Inter- and intra-observer concordance and correlation with overall response and progression-free survival (PFS) were performed. Results Method 1 produced the highest inter-observer concordance and was used to calculate the relative extension scores (post-therapy score divided by pre-therapy score), which correlated significantly with overall response. Patients who achieved complete response (CR) or partial response (PR) (n = 21) had lower relative extension scores, compared to those without response ( P < 0.001). The readers' overall impression associated highly ( P < 0.001) with the relative extension scores though results were less quantitative. Concordance was higher if initial scores were >5. Relative extension score did not predict PFS. Conclusion Semi-quantitative scoring of mIBG scans provides a more reliable method of assessing response in patients with relapsed neuroblastoma than qualitative impression. The reproducibility and high inter-observer concordance makes mIBG score an important component of overall response criteria in patients with recurrent neuroblastoma. Pediatr Blood Cancer © 2006 Wiley-Liss, Inc. | en_US |
dc.format.extent | 348702 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Evaluation of semi-quantitative scoring system for metaiodobenzylguanidine (mIBG) scans in patients with relapsed neuroblastoma | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Nuclear Medicine, St. Jude Children's Research Hospital, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Pediatrics, University of California, San Francisco, California | en_US |
dc.contributor.affiliationother | Department of Epidemiology and Biostatistics, University of California, San Francisco, California | en_US |
dc.contributor.affiliationother | Department of Nuclear Medicine, University of California, San Francisco, California | en_US |
dc.contributor.affiliationother | Department of Nuclear Medicine, Hospital for Sick Children, University of Toronto, Toronto, Canada | en_US |
dc.contributor.affiliationother | Department of Nuclear Medicine, University of California, San Francisco, California | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania | en_US |
dc.contributor.affiliationother | Department of Nuclear Medicine, University of California, San Francisco, California | en_US |
dc.contributor.affiliationother | Department of Pediatrics, University of California, San Francisco, California ; Department of Pediatrics, Box 0106, University of California, San Francisco, CA 94143. | en_US |
dc.identifier.pmid | 16444675 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/55847/1/20777_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/pbc.20777 | en_US |
dc.identifier.source | Pediatric Blood & Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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