Show simple item record

dc.contributor.authorSun, Yan-Xien_US
dc.contributor.authorFang, Mingen_US
dc.contributor.authorWang, Jianhuaen_US
dc.contributor.authorCooper, Carlton R.en_US
dc.contributor.authorPienta, Kenneth J.en_US
dc.contributor.authorTaichman, Russell S.en_US
dc.date.accessioned2007-09-20T17:54:36Z
dc.date.available2008-04-03T18:44:56Zen_US
dc.date.issued2007-01-01en_US
dc.identifier.citationSun, Yan-Xi; Fang, Ming; Wang, Jianhua; Cooper, Carlton R.; Pienta, Kenneth J.; Taichman, Russell S. (2007). "Expression and activation of Α v Β 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells." The Prostate 67(1): 61-73. <http://hdl.handle.net/2027.42/55878>en_US
dc.identifier.issn0270-4137en_US
dc.identifier.issn1097-0045en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/55878
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17034033&dopt=citationen_US
dc.description.abstractBACKGROUND Stromal cell-derived factor-1 (SDF-1 or CXCL12) and CXCR4 are key elements in the metastasis of prostate cancer cells to bone—but the mechanisms as to how it localizes to the marrow remains unclear. METHODS Prostate cancer cell lines were stimulated with SDF-1 and evaluated for alterations in the expression of adhesion molecules using microarrays, FACs, and Western blotting to identify Α v Β 3 receptors. Cell–cell adhesion and invasion assays were used to verify that activation of the receptor is responsive to SDF-1. RESULTS We demonstrate that SDF-1 transiently regulates the number and affinity of Α v Β 3 receptors by prostate cancer cells to enhance their metastatic behavior by increasing adhesiveness and invasiveness. SDF-1 transiently increased the expression of Β 3 receptor subunit and increased its phosphorylation in metastatic but not nonmetastatic cells. CONCLUSIONS The transition from a locally invasive phenotype to a metastatic phenotype may be primed by the elevated expression of Α v Β 3 receptors. Activation and increased expression of Α v Β 3 within SDF-1-rich organs may participate in metastatic localization. Prostate 67:61–73, 2007. © 2006 Wiley-Liss, Inc.en_US
dc.format.extent491198 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCancer Research, Oncology and Pathologyen_US
dc.titleExpression and activation of Α v Β 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cellsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan School of Medicine, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartments of Urology and Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan ; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, MI 48109-1078.en_US
dc.contributor.affiliationotherDepartment of Biological Sciences, University of Delaware, Newark, Delawareen_US
dc.identifier.pmid17034033en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/55878/1/20500_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/pros.20500en_US
dc.identifier.sourceThe Prostateen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record