Unrelated donor bone marrow transplantation using a chemotherapy-only preparative regimen for adults with high-risk acute myelogenous leukemia
dc.contributor.author | Ayash, Lois J. | en_US |
dc.contributor.author | Ratanatharathorn, Voravit | en_US |
dc.contributor.author | Braun, Thomas | en_US |
dc.contributor.author | Silver, Samuel M. | en_US |
dc.contributor.author | Reynolds, Christopher M. | en_US |
dc.contributor.author | Uberti, Joseph P. | en_US |
dc.date.accessioned | 2007-09-20T17:56:25Z | |
dc.date.available | 2008-04-03T18:45:17Z | en_US |
dc.date.issued | 2007-01 | en_US |
dc.identifier.citation | Ayash, Lois J.; Ratanatharathorn, Voravit; Braun, Thomas; Silver, Samuel M.; Reynolds, Christopher M.; Uberti, Joseph P. (2007). "Unrelated donor bone marrow transplantation using a chemotherapy-only preparative regimen for adults with high-risk acute myelogenous leukemia." American Journal of Hematology 82(1): 6-14. <http://hdl.handle.net/2027.42/55885> | en_US |
dc.identifier.issn | 0361-8609 | en_US |
dc.identifier.issn | 1096-8652 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/55885 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16986128&dopt=citation | en_US |
dc.description.abstract | Limited data are available for adults undergoing unrelated donor (URD) BMT for AML using chemotherapy-only preparative regimens. Previous studies incorporated irradiation, included adults and children, and excluded secondary leukemia. Herein we report long-term outcomes for adults with poor-prognostic AML receiving a novel regimen of busulfan (16 mg/kg), cytarabine (8,000 mg/m 2 ), and cyclophosphamide (120 mg/kg) (BAC), followed by URD BMT. From June 1995 through October 2001, 45 adults were enrolled. Adverse features included unfavorable cytogenetics (49%), secondary AML (47%), leukemia at transplant (42%), and extramedullary disease (16%). At time of BMT, 23 were in remission (12 CR1) while 22 had leukemia. Four (9%) died early. Acute and chronic GVHD rates were 44 and 67%, respectively. Seventeen (38%) were disease-free 52 months post-BMT; 13 were leukemia-free (eight CR1) at transplant. Eleven relapsed. Three-year DFS and OS were 42 and 46%, respectively. DFS and OS were longer, and relapses less, for those in CR at time of BMT. Secondary leukemia, cytogenetics, cell dose, and GVHD did not influence outcome. In poor-risk AML, BAC provided cytoreduction comparable to reported TBI-containing regimens, when administered for URD BMT. With decreasing treatment-related mortality, it is justified to proceed early to URD BMT for patients with poor prognostic features. Am. J. Hematol., 2006. © 2006 Wiley-Liss, Inc. | en_US |
dc.format.extent | 145865 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Unrelated donor bone marrow transplantation using a chemotherapy-only preparative regimen for adults with high-risk acute myelogenous leukemia | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan ; Karmanos Cancer Institute, 4100 John R, 4HWCRC, Detroit, MI 48201 | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan Medical Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 16986128 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/55885/1/20759_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ajh.20759 | en_US |
dc.identifier.source | American Journal of Hematology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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