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dc.contributor.authorZmarowski, Amyen_US
dc.contributor.authorSarter, Martinen_US
dc.contributor.authorBruno, John P.en_US
dc.date.accessioned2007-09-20T17:58:24Z
dc.date.available2008-04-03T18:45:48Zen_US
dc.date.issued2007-03en_US
dc.identifier.citationZmarowski, Amy; Sarter, Martin; Bruno, John P. (2007). "Glutamate receptors in nucleus accumbens mediate regionally selective increases in cortical acetylcholine release." Synapse 61(3): 115-123. <http://hdl.handle.net/2027.42/55892>en_US
dc.identifier.issn0887-4476en_US
dc.identifier.issn1098-2396en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/55892
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17146770&dopt=citationen_US
dc.description.abstractThe basal forebrain cortical cholinergic system (BFCS) is critical for the regulation of attentional information processing. BFCS activity is regulated by several cortical and subcortical structures, including the nucleus accumbens (NAC) and prefrontal cortex (PFC). GABAergic projection neurons from NAC to basal forebrain are modulated by Glu receptors within NAC. We previously reported that intra-NAC perfusions of NMDA or its antagonist CPP stimulate ACh release in PFC. In this experiment we determined whether this trans-synaptic modulation of cortical ACh release is evident in multi-sensory associational areas like the posterior parietal cortex (PPC). Artificial cerebrospinal fluid (aCSF, control), NMDA (250 or 400 ΜM), or CPP (200 or 400 ΜM) were perfused into the NAC shell and ACh was measured in the ipsilateral PPC. Amphetamine (2.0 mg/kg, i.p), was systemically administered as a positive control in a fourth session, since it also stimulates cortical ACh release but via mechanisms known to not necessitate transmission within the NAC. Neither NMDA nor CPP increased ACh efflux in the PPC, yet both drugs increased ACh release in PFC, suggesting that NMDA receptor modulation in the NAC increases ACh in the cortex in a regionally-specific manner. Systemic amphetamine administration significantly increased (100–200%) ACh in the PPC, suggesting that levels of ACh in the PPC can be increased following certain pharmacological manipulations. The cortical region-specific modulation of ACh by NAC may underlie the linkage of motivational information with top-down controls of attention as well as guide appropriate motor output following exposure to salient and behaviorally relevant stimuli. Synapse 61:115–123, 2007. © 2006 Wiley-Liss, Inc.en_US
dc.format.extent230075 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleGlutamate receptors in nucleus accumbens mediate regionally selective increases in cortical acetylcholine releaseen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherDepartment of Psychology, The Ohio State University, Columbus, Ohioen_US
dc.contributor.affiliationotherDepartment of Psychology, The Ohio State University, Columbus, Ohio ; Department of Neuroscience, The Ohio State University, Columbus, Ohio ; Dept. of Psychology, 57 Psychology Building, The Ohio State University, Columbus, OH 43210en_US
dc.identifier.pmid17146770en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/55892/1/20354_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/syn.20354en_US
dc.identifier.sourceSynapseen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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