Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance
dc.contributor.author | Schepkin, Victor D. | en_US |
dc.contributor.author | Lee, Kuei C. | en_US |
dc.contributor.author | Kuszpit, Kyle | en_US |
dc.contributor.author | Muthuswami, Mukilan | en_US |
dc.contributor.author | Johnson, Timothy D. | en_US |
dc.contributor.author | Chenevert, Thomas L. | en_US |
dc.contributor.author | Rehemtulla, Alnawaz | en_US |
dc.contributor.author | Ross, Brian D. | en_US |
dc.date.accessioned | 2007-09-20T18:00:21Z | |
dc.date.available | 2008-01-03T16:22:17Z | en_US |
dc.date.issued | 2006-12 | en_US |
dc.identifier.citation | Schepkin, Victor D.; Lee, Kuei C.; Kuszpit, Kyle; Muthuswami, Mukilan; Johnson, Timothy D.; Chenevert, Thomas L.; Rehemtulla, Alnawaz; Ross, Brian D. (2006). "Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance." NMR in Biomedicine 19(8): 1035-1042. <http://hdl.handle.net/2027.42/55899> | en_US |
dc.identifier.issn | 0952-3480 | en_US |
dc.identifier.issn | 1099-1492 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/55899 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16894643&dopt=citation | en_US |
dc.description.abstract | The ultimate goal of any cancer therapy is to target the elimination of neoplastic cells. Although newer therapeutic strategies are in constant development, therapeutic assessment has been hampered by the inability to assess, rapidly and quantitatively, efficacy in vivo . Diffusion imaging and, more recently, sodium MRI have demonstrated their distinct abilities to detect therapy-induced alterations in tumor cellularity, which has been demonstrated to be indicative of therapeutic efficacy. More importantly, both imaging modalities detect tumor response much earlier than traditional methodologies that rely on macroscopic volumetric changes. In this study, the correlation between tumor sodium and diffusion was further tested to demonstrate the sensitivity of sodium imaging to gauge tumor response to therapy by using a 9L rat gliosarcoma treated with varying doses of BCNU [1,3-bis(2-chloroethyl)-1-nitrosourea]. This orthotopic model has been demonstrated to display variability in response to BCNU therapy where initial insult has been shown to lead to drug-resistance. In brief, a single 26.6 mg/kg BCNU dose yielded dramatic responses in both diffusion and sodium MRI. However, a second equivalent BCNU dose yielded a much smaller change in diffusion and sodium, suggesting a drop in tumor sensitivity to BCNU. The MRI responses of animals treated with 13.3 mg/kg BCNU were much lower and similar responses were observed after the initial and secondary applications of BCNU. Furthermore, these results were further validated using volumetric measurements of the tumor and also ex vivo determination of tumor sensitivity to BCNU. Overall, these experiments demonstrate the sensitivity and applicability of sodium and diffusion MRI as tools for dynamic assessment of tumor response to therapy. Copyright © 2006 John Wiley & Sons, Ltd. | en_US |
dc.format.extent | 280255 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | John Wiley & Sons, Ltd. | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Analytical Chemistry and Spectroscopy | en_US |
dc.title | Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Electrical Engineering | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA ; Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109-0503, USA ; National High Magnetic Field Laboratory, 1800 East Paul Dirac Dr., Tallahassee, FL 32310, USA. | en_US |
dc.contributor.affiliationum | Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109-0503, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109-0503, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109-0503, USA | en_US |
dc.contributor.affiliationum | Department of Biostatistics, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109-0503, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109-0503, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109-0503, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109-0503, USA | en_US |
dc.identifier.pmid | 16894643 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/55899/1/1074_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/nbm.1074 | en_US |
dc.identifier.source | NMR in Biomedicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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