Does colonoscopy cause increased ulcerative colitis symptoms?
dc.contributor.author | Menees, Stacy B. | en_US |
dc.contributor.author | Higgins, Peter D.R. | en_US |
dc.contributor.author | Korsnes, Sheryl | en_US |
dc.contributor.author | Elta, Grace H. | en_US |
dc.date.accessioned | 2007-09-20T18:02:02Z | |
dc.date.available | 2008-04-03T18:47:03Z | en_US |
dc.date.issued | 2007-01 | en_US |
dc.identifier.citation | Menees, Stacy; Higgins, Peter; Korsnes, Sheryl; Elta, Grace (2007). "Does colonoscopy cause increased ulcerative colitis symptoms?." Inflammatory Bowel Diseases 13(1): 12-18. <http://hdl.handle.net/2027.42/55905> | en_US |
dc.identifier.issn | 1078-0998 | en_US |
dc.identifier.issn | 1536-4844 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/55905 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17206634&dopt=citation | en_US |
dc.description.abstract | Background: Ulcerative colitis (UC) patients often report symptom flares after colonoscopy. However, this has not been documented in the literature. Objectives: 1. Determine whether colonoscopy is associated with increased UC symptoms. 2. Determine whether there is a need for escalation of UC medications after colonoscopy. 3. Identify baseline variables associated with increased symptoms after colonoscopy. Methods: Firty-five outpatients with a history of UC, intact colon, and quiescent disease were enrolled in a prospective case-crossover study. Subjects were evaluated with the Simple Clinical Colitis Activity Index (SCCAI) before colonoscopy, 1 week and 4 weeks after colonoscopy. A mixed model analysis was used to accommodate nonindependence of repeated measurements on the same patients. Results: Fifty-one (91%) subjects completed the study. Six subjects had clinical relapse defined by a score of 5 or greater on the SCCAI during the week after colonoscopy. Five subjects increased their 5-aminosalicylic acid (5-ASA) medications immediately postcolonoscopy, two of whom had a SCCAI 5 or greater. Multivariate modeling demonstrated a clear association between the week immediately after colonoscopy preparation and increased disease activity, with the time period being predictive of increased SCCAI (week 1 vs. week 4, P = 0.0127). The baseline SCCAI ( P value < 0.0001) and prednisone use ( P = 0.0120) were predictive of increased SCCAI postcolonoscopy. Thiopurines ( P < 0.001) were protective against increased symptoms. Conclusions: In our study, 1 in 8 subjects had UC relapse by SCCAI immediately postcolonoscopy, and 1 in 10 subjects required an increase in their 5-ASA medications. Clinicians should be cognizant of this effect of colonoscopy in patients with UC. (Inflamm Bowel Dis 2007;13:12–18) | en_US |
dc.format.extent | 124760 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Surgery | en_US |
dc.title | Does colonoscopy cause increased ulcerative colitis symptoms? | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Eastern Virginia Medical School, Norfolk, VA ; 3912 Taubman Center, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109-0362 | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.identifier.pmid | 17206634 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/55905/1/20049_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ibd.20049 | en_US |
dc.identifier.source | Inflammatory Bowel Diseases | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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