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Outcomes in hepatitis C virus–infected recipients of living donor vs. deceased donor liver transplantation

dc.contributor.authorTerrault, Norah A.en_US
dc.contributor.authorShiffman, Mitchell L.en_US
dc.contributor.authorLok, Anna Suk-Fongen_US
dc.contributor.authorSaab, Sammyen_US
dc.contributor.authorTong, Lanen_US
dc.contributor.authorBrown, Robert S.en_US
dc.contributor.authorEverson, Gregory T.en_US
dc.contributor.authorReddy, K. Rajenderen_US
dc.contributor.authorFair, Jeffrey H.en_US
dc.contributor.authorKulik, Laura M.en_US
dc.contributor.authorPruett, Timothy L.en_US
dc.contributor.authorSeeff, Leonard B.en_US
dc.date.accessioned2007-09-20T18:04:38Z
dc.date.available2008-04-03T18:47:24Zen_US
dc.date.issued2007-01en_US
dc.identifier.citationTerrault, Norah A.; Shiffman, Mitchell L.; Lok, Anna S.F.; Saab, Sammy; Tong, Lan; Brown, Robert S.; Everson, Gregory T.; Reddy, K. Rajender; Fair, Jeffrey H.; Kulik, Laura M.; Pruett, Timothy L.; Seeff, Leonard B. (2007). "Outcomes in hepatitis C virus–infected recipients of living donor vs. deceased donor liver transplantation Presented in part at the American Association for the Study of Liver Diseases, 56 th Annual Meeting, San Francisco, CA, November 11-15, 2005. Publication number 2 of the Adult-to-Adult Living Donor Liver Transplantation Cohort Study. Supplemental data have been supplied by the University Renal Research and Education Association as the contractor for the Scientific Registry of Transplant Recipients. The interpretation and reporting of these data are the responsibility of the author(s) and in no way should be seen as an official policy of or interpretation by the Scientific Registry of Transplant Recipients or the U.S. government. See Editorial on Page 18 ." Liver Transplantation 13(1): 122-129. <http://hdl.handle.net/2027.42/55915>en_US
dc.identifier.issn1527-6465en_US
dc.identifier.issn1527-6473en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/55915
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17192908&dopt=citationen_US
dc.description.abstractIn this retrospective study of hepatitis C virus (HCV)–infected transplant recipients in the 9-center Adult to Adult Living Donor Liver Transplantation Cohort Study, graft and patient survival and the development of advanced fibrosis were compared among 181 living donor liver transplant (LDLT) recipients and 94 deceased donor liver transplant (DDLT) recipients. Overall 3-year graft and patient survival were 68% and 74% in LDLT, and 80% and 82% in DDLT, respectively. Graft survival, but not patient survival, was significantly lower for LDLT compared to DDLT ( P = 0.04 and P = 0.20, respectively). Further analyses demonstrated lower graft and patient survival among the first 20 LDLT cases at each center (LDLT <20) compared to later cases (LDLT > 20; P = 0.002 and P = 0.002, respectively) and DDLT recipients ( P < 0.001 and P = 0.008, respectively). Graft and patient survival in LDLT >20 and DDLT were not significantly different ( P = 0.66 and P = 0.74, respectively). Overall, 3-year graft survival for DDLT, LDLT >20, and LDLT <20 were 80%, 79% and 55%, with similar results conditional on survival to 90 days (84%, 87% and 68%, respectively). Predictors of graft loss beyond 90 days included LDLT <20 vs. DDLT (hazard ratio [HR] = 2.1, P = 0.04), pretransplant hepatocellular carcinoma (HCC) (HR = 2.21, P = 0.03) and model for end-stage liver disease (MELD) at transplantation (HR = 1.24, P = 0.04). In conclusion, 3-year graft and patient survival in HCV-infected recipients of DDLT and LDLT >20 were not significantly different. Important predictors of graft loss in HCV-infected patients were limited LDLT experience, pretransplant HCC, and higher MELD at transplantation. Liver Transpl 13:122–129, 2007. © 2006 AASLD.en_US
dc.format.extent171775 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherSurgeryen_US
dc.titleOutcomes in hepatitis C virus–infected recipients of living donor vs. deceased donor liver transplantationen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Surgery, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationotherDepartment of Medicine, Division of Gastroenterology, University of California at San Francisco, San Francisco, CAen_US
dc.contributor.affiliationotherDepartment of Medicine, Division of Gastroenterology, Virginia Commonwealth University Medical Center, Richmond, VAen_US
dc.contributor.affiliationotherDepartment of Medicine, University of California, Los Angeles, Los Angeles, CAen_US
dc.contributor.affiliationotherDepartment of Medicine, Columbia University Medical Center, New York, NYen_US
dc.contributor.affiliationotherDepartment of Medicine, Division of Gastroenterology, University of Colorado, Denver, COen_US
dc.contributor.affiliationotherDepartment of Medicine, Division of Gastroenteology, University of Pennsylvania, Philadelphia, PAen_US
dc.contributor.affiliationotherDepartment of Surgery, University of North Carolina, Chapel Hill, NCen_US
dc.contributor.affiliationotherDepartment of Medicine, Division of Gastroenterology, Northwestern University, Chicago, ILen_US
dc.contributor.affiliationotherDepartment of Surgery, University of Virginia, Charlottesville, VAen_US
dc.contributor.affiliationotherNational Instutes of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MDen_US
dc.identifier.pmid17192908en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/55915/1/20995_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/lt.20995en_US
dc.identifier.sourceLiver Transplantationen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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