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dc.contributor.authorThakur, Jagdish S.en_US
dc.contributor.authorDai, Houbeien_US
dc.contributor.authorSerhatkulu, Gulay K.en_US
dc.contributor.authorNaik, Ratnaen_US
dc.contributor.authorNaik, Vaman M.en_US
dc.contributor.authorCao, Alexen_US
dc.contributor.authorPandya, Abhilashen_US
dc.contributor.authorAuner, Gregory W.en_US
dc.contributor.authorRabah, Rajahen_US
dc.contributor.authorKlein, Michael D.en_US
dc.contributor.authorFreeman, Carlen_US
dc.date.accessioned2007-09-20T18:12:53Z
dc.date.available2008-04-03T18:49:56Zen_US
dc.date.issued2007-02en_US
dc.identifier.citationThakur, Jagdish S.; Dai, Houbei; Serhatkulu, Gulay K.; Naik, Ratna; Naik, Vaman M.; Cao, Alex; Pandya, Abhilash; Auner, Gregory W.; Rabah, Rajah; Klein, Michael D.; Freeman, Carl (2007). "Raman spectral signatures of mouse mammary tissue and associated lymph nodes: normal, tumor and mastitis." Journal of Raman Spectroscopy 38(2): 127-134. <http://hdl.handle.net/2027.42/55947>en_US
dc.identifier.issn0377-0486en_US
dc.identifier.issn1097-4555en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/55947
dc.description.abstractRaman spectroscopy involves the interaction of light with the molecular vibrations and therefore can provide information about molecular structure, tissue composition and changes in its environment. We explored whether Raman spectroscopy can reliably distinguish mammary tumors from normal mammary tissues and other pathological states in mice. We analyzed a large number of Raman spectra from the tumor and normal mammary glands of mice injected with 4T1 tumor cells, which were collected using a high-resolution (less than 4 cm −1 ) Raman spectrometer at a fixed (785 nm) laser excitation wavelength and with 60 mW of laser power. The spectra of normal and tumor mammary glands showed consistent differences in the intensity of certain Raman bands and loss of some bands in the tumor spectra. Multivariate statistical methods—principal component analysis (PCA) and discriminant functional analysis (DFA)—were used to separate the data into different groups of mammary tumors, mastitis, lymph nodes contralateral and tumor-cell-injected sides, and normal contralateral and tumor-cell-injected sides. We demonstrate that this spectroscopic technique has the feasibility of discriminating tumor and mastitis from normal tissues and other pathological states in a short period of time and may detect tumor transformation earlier than the standard histological examination stage. Copyright © 2006 John Wiley & Sons, Ltd.en_US
dc.format.extent1006758 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherJohn Wiley & Sons, Ltd.en_US
dc.subject.otherChemistryen_US
dc.subject.otherAnalytical Chemistry and Spectroscopyen_US
dc.titleRaman spectral signatures of mouse mammary tissue and associated lymph nodes: normal, tumor and mastitisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Natural Sciences, University of Michigan-Dearborn, Dearborn, MI 48128, USAen_US
dc.contributor.affiliationotherDepartment of Electrical and Computer Engineering, Wayne State University, Detroit, MI 48202, USA ; Department of Electrical and Computer Engineering, Wayne State University, Detroit, MI 48202, USA.en_US
dc.contributor.affiliationotherDepartment of Physics and Astronomy, Wayne State University, Detroit, MI 48202, USAen_US
dc.contributor.affiliationotherDepartment of Electrical and Computer Engineering, Wayne State University, Detroit, MI 48202, USAen_US
dc.contributor.affiliationotherDepartment of Physics and Astronomy, Wayne State University, Detroit, MI 48202, USAen_US
dc.contributor.affiliationotherDepartment of Electrical and Computer Engineering, Wayne State University, Detroit, MI 48202, USAen_US
dc.contributor.affiliationotherDepartment of Electrical and Computer Engineering, Wayne State University, Detroit, MI 48202, USAen_US
dc.contributor.affiliationotherDepartment of Electrical and Computer Engineering, Wayne State University, Detroit, MI 48202, USAen_US
dc.contributor.affiliationotherDepartments of Surgery (Pediatric Surgery) and Pathology, Wayne State University School of Medicine and the Children's Hospital of Michigan, Detroit, MI 48201, USAen_US
dc.contributor.affiliationotherDepartments of Surgery (Pediatric Surgery) and Pathology, Wayne State University School of Medicine and the Children's Hospital of Michigan, Detroit, MI 48201, USAen_US
dc.contributor.affiliationotherDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/55947/1/1565_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/jrs.1565en_US
dc.identifier.sourceJournal of Raman Spectroscopyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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