Palladium-Catalyzed Carboetherification and Carboamination Reactions of Γ-Hydroxy- and Γ-Aminoalkenes for the Synthesis of Tetrahydrofurans and Pyrrolidines

Abstract

Substituted tetrahydrofuran and pyrrolidine moieties are displayed in a wide range of interesting biologically active molecules. The Pd-catalyzed carboetherification or carboamination of Γ-hydroxy and Γ-aminoalkenes is a powerful tool for the construction of these heterocycles, as it is convergent and can allow access to a variety of analogs from a single Γ-hydroxy- or Γ-aminoalkene starting material. This microreview describes the current state of this field. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)