Specific extra chromosomes occur in a modal number dependent pattern in pediatric acute lymphoblastic leukemia A complete listing of grant support for research conducted by CCG and POG before initiation of the COG grant in 2003 is available online at: http://www.childrensoncologygroup.org/admin/grantinfo.htm
dc.contributor.author | Heerema, Nyla A. | en_US |
dc.contributor.author | Raimondi, Susana C. | en_US |
dc.contributor.author | Anderson, James R. | en_US |
dc.contributor.author | Biegel, Jaclyn | en_US |
dc.contributor.author | Camitta, Bruce M. | en_US |
dc.contributor.author | Cooley, Linda D. | en_US |
dc.contributor.author | Gaynon, Paul S. | en_US |
dc.contributor.author | Hirsch, Betsy | en_US |
dc.contributor.author | Magenis, R. Ellen | en_US |
dc.contributor.author | McGavran, Loris | en_US |
dc.contributor.author | Patil, Shivanand R. | en_US |
dc.contributor.author | Pettenati, Mark J. | en_US |
dc.contributor.author | Pullen, Jeanette | en_US |
dc.contributor.author | Rao, Kathleen | en_US |
dc.contributor.author | Roulston, Diane | en_US |
dc.contributor.author | Schneider, Nancy R. | en_US |
dc.contributor.author | Shuster, Jonathan J. | en_US |
dc.contributor.author | Sanger, Warren | en_US |
dc.contributor.author | Sutcliffe, Maxine J. | en_US |
dc.contributor.author | van Tuinen, Peter | en_US |
dc.contributor.author | Watson, Michael S. | en_US |
dc.contributor.author | Carroll, Andrew J. | en_US |
dc.date.accessioned | 2007-09-20T18:32:31Z | |
dc.date.available | 2008-09-08T14:25:13Z | en_US |
dc.date.issued | 2007-07 | en_US |
dc.identifier.citation | Heerema, Nyla A.; Raimondi, Susana C.; Anderson, James R.; Biegel, Jaclyn; Camitta, Bruce M.; Cooley, Linda D.; Gaynon, Paul S.; Hirsch, Betsy; Magenis, R. Ellen; McGavran, Loris; Patil, Shivanand; Pettenati, Mark J.; Pullen, Jeanette; Rao, Kathleen; Roulston, Diane; Schneider, Nancy R.; Shuster, Jonathan J.; Sanger, Warren; Sutcliffe, Maxine J.; van Tuinen, Peter; Watson, Michael S.; Carroll, Andrew J (2007)."Specific extra chromosomes occur in a modal number dependent pattern in pediatric acute lymphoblastic leukemia A complete listing of grant support for research conducted by CCG and POG before initiation of the COG grant in 2003 is available online at: http://www.childrensoncologygroup.org/admin/grantinfo.htm ." Genes, Chromosomes and Cancer 46(7): 684-693. <http://hdl.handle.net/2027.42/56022> | en_US |
dc.identifier.issn | 1045-2257 | en_US |
dc.identifier.issn | 1098-2264 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56022 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17431878&dopt=citation | en_US |
dc.description.abstract | Children with acute lymphoblastic leukemia (ALL) and high hyperdiploidy (>50 chromosomes) are considered to have a relatively good prognosis. The specific extra chromosomes are not random; extra copies of some chromosomes occur more frequently than those of others. We examined the extra chromosomes present in high hyperdiploid ALL to determine if there were a relation of the specific extra chromosomes and modal number (MN) and if the extra chromosomes present could differentiate high hyperdiploid from near-triploid and near-tetraploid cases. Karyotypes of 2,339 children with ALL and high hyperdiploidy at diagnosis showed a distinct nonrandom sequential pattern of gain for each chromosome as MN increased, with four groups of gain: chromosomes 21, X, 14, 6, 18, 4, 17, and 10 at MN 51–54; chromosomes 8, 5, 11, and 12 at MN 57–60; chromosomes 2, 3, 9,16, and 22 at MN 63–67; chromosomes 1, 7 13, 15, 19, and 20 at MN 68–79, and Y only at MN ≥≥80. Chromosomes gained at lower MN were retained as the MN increased. High hyperdiploid pediatric ALL results from a single abnormal mitotic division. Our results suggest that the abnormal mitosis involves specific chromosomes dependent on the number of chromosomes aberrantly distributed, raising provocative questions regarding the mitotic mechanism. The patterns of frequencies of tetrasomy of specific chromosomes differs from that of trisomies with the exception of chromosome 21, which is tetrasomic in a high frequency of cases at all MN. These results are consistent with different origins of high hyperdiploidy, near-trisomy, and near-tetrasomy. © 2007 Wiley-Liss, Inc. | en_US |
dc.format.extent | 330218 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Specific extra chromosomes occur in a modal number dependent pattern in pediatric acute lymphoblastic leukemia A complete listing of grant support for research conducted by CCG and POG before initiation of the COG grant in 2003 is available online at: http://www.childrensoncologygroup.org/admin/grantinfo.htm | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Department of Pathology, The Ohio State University, Columbus, OH ; Columbus Children's Hospital, The Ohio State University, 167 Hamilton Hall, 1645 Neil Ave., Columbus, OH 43210, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN | en_US |
dc.contributor.affiliationother | Department of Biostatistics, University of Nebraska Medical Center, Omaha, NB | en_US |
dc.contributor.affiliationother | Division of Genetics, Childrens Hospital of Philadelphia, Philadelphia, PA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Midwest Children's Cancer Center, Milwaukee, WI | en_US |
dc.contributor.affiliationother | Cytogenetics Laboratory, The Childrens Mercy Hospital, Kansas City, MO | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Childrens Hospital Los Angeles, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Laboratory Medicine and Pathology, University of Minnesota Cancer Center, Minneapolis, MN | en_US |
dc.contributor.affiliationother | Department of Molecular and Medical Genetics/Cytogenetics Laboratory, Oregon Health Sciences University, Portland, OR | en_US |
dc.contributor.affiliationother | Genetics Laboratory, University of Colorado Health Sciences Center, Denver, CO | en_US |
dc.contributor.affiliationother | Department of Pediatrics, University of Iowa, Iowa City, IA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Wake Forest University, Winston-Salem, NC | en_US |
dc.contributor.affiliationother | Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS | en_US |
dc.contributor.affiliationother | Departments of Pediatrics and Pathology/Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Texas, Southwestern Medical Center, Dallas, TX | en_US |
dc.contributor.affiliationother | Children's Oncology Group Statistics and Data Center and the Department of Epidemiology and Health Policy Research, University of Florida, Gainesville, FL | en_US |
dc.contributor.affiliationother | Center for Human Genetics, University of Nebraska, Omaha, NE | en_US |
dc.contributor.affiliationother | Departments of Pathology and Pediatrics, All Children's Hospital, St Petersburg, FL | en_US |
dc.contributor.affiliationother | Department of Pathology, Medical College of Wisconsin, Milwaukee, WI | en_US |
dc.contributor.affiliationother | American College of Medical Genetics, Bethesda, MD | en_US |
dc.contributor.affiliationother | Department of Genetics, University of Alabama at Birmingham, Birmingham, AL | en_US |
dc.identifier.pmid | 17431878 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56022/1/20451_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/gcc.20451 | en_US |
dc.identifier.source | Genes, Chromosomes and Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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