A Mixed Model-Based Variance Estimator for Marginal Model Analyses of Cluster Randomized Trials
dc.contributor.author | Braun, Thomas M. | en_US |
dc.date.accessioned | 2007-09-20T18:45:33Z | |
dc.date.available | 2008-09-08T14:25:13Z | en_US |
dc.date.issued | 2007-06 | en_US |
dc.identifier.citation | Braun, Thomas M. (2007)."A Mixed Model-Based Variance Estimator for Marginal Model Analyses of Cluster Randomized Trials." Biometrical Journal 49(3): 394-405. <http://hdl.handle.net/2027.42/56069> | en_US |
dc.identifier.issn | 0323-3847 | en_US |
dc.identifier.issn | 1521-4036 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56069 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17623344&dopt=citation | en_US |
dc.description.abstract | Generalized estimating equations (GEE) are used in the analysis of cluster randomized trials (CRTs) because: 1) the resulting intervention effect estimate has the desired marginal or population-averaged interpretation, and 2) most statistical packages contain programs for GEE. However, GEE tends to underestimate the standard error of the intervention effect estimate in CRTs. In contrast, penalized quasi-likelihood (PQL) estimates the standard error of the intervention effect in CRTs much better than GEE but is used less frequently because: 1) it generates an intervention effect estimate with a conditional, or cluster-specific, interpretation, and 2) PQL is not a part of most statistical packages. We propose taking the variance estimator from PQL and re-expressing it as a sandwich-type estimator that could be easily incorporated into existing GEE packages, thereby making GEE useful for the analysis of CRTs. Using numerical examples and data from an actual CRT, we compare the performance of this variance estimator to others proposed in the literature, and we find that our variance estimator performs as well as or better than its competitors. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) | en_US |
dc.format.extent | 121405 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Epidemiology, Biostatistics and Public Health | en_US |
dc.title | A Mixed Model-Based Variance Estimator for Marginal Model Analyses of Cluster Randomized Trials | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan, 1420 Washington Heights, M4063 SPH II, Ann Arbor, MI 48109, USA ; Phone: +1 734 936 9844, Fax: +1 173 763 2215 | en_US |
dc.identifier.pmid | 17623344 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56069/1/394_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/bimj.200510280 | en_US |
dc.identifier.source | Biometrical Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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