Dendrimer-Entrapped Gold Nanoparticles as a Platform for Cancer-Cell Targeting and Imaging
dc.contributor.author | Shi, Xiangyang | en_US |
dc.contributor.author | Wang, Su He | en_US |
dc.contributor.author | Meshinchi, Sasha | en_US |
dc.contributor.author | Van Antwerp, Mary e. | en_US |
dc.contributor.author | Bi, Xiangdong | en_US |
dc.contributor.author | Lee, Inhan | en_US |
dc.contributor.author | Baker, James R. Jr. | en_US |
dc.date.accessioned | 2007-09-20T18:55:10Z | |
dc.date.available | 2008-09-08T14:25:12Z | en_US |
dc.date.issued | 2007-07-02 | en_US |
dc.identifier.citation | Shi, Xiangyang; Wang, Suhe; Meshinchi, Sasha; Van Antwerp, Mary 14E.; Bi, Xiangdong; Lee, Inhan; Baker, James 14R. (2007)."Dendrimer-Entrapped Gold Nanoparticles as a Platform for Cancer-Cell Targeting and Imaging." Small 3(7): 1245-1252. <http://hdl.handle.net/2027.42/56102> | en_US |
dc.identifier.issn | 1613-6810 | en_US |
dc.identifier.issn | 1613-6829 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56102 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17523182&dopt=citation | en_US |
dc.description.abstract | We present a general approach for the targeting and imaging of cancer cells using dendrimer-entrapped gold nanoparticles (Au DENPs). Au DENPs were found to be able to covalently link with targeting and imaging ligands for subsequent cancer-cell targeting and imaging. The Au DENPs linked with defined numbers of folic acid (FA) and fluorescein isothiocyanate (FI) molecules are water soluble, stable, and biocompatible. In 14vitro studies show that the FA- and FI-modified Au DENPs can specifically bind to KB cells (a human epithelial carcinoma cell line) that overexpress high-affinity folate receptors and they are internalized dominantly into lysosomes of target cells within 2 14h. These findings demonstrate that Au DENPs may serve as a general platform for cancer imaging and therapeutics. | en_US |
dc.format.extent | 544475 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Polymers and Materials Science | en_US |
dc.subject.other | General Materials Science | en_US |
dc.title | Dendrimer-Entrapped Gold Nanoparticles as a Platform for Cancer-Cell Targeting and Imaging | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA, Fax: (+1) 14734-615-2506 ; | en_US |
dc.contributor.affiliationum | Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA, Fax: (+1) 14734-615-2506 ; | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA, Fax: (+1) 14734-615-2506 | en_US |
dc.contributor.affiliationum | Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA, Fax: (+1) 14734-615-2506 | en_US |
dc.contributor.affiliationum | Michigan Center for Biological Information and Department of Psychiatry, University of Michigan, 3600 Green Court, Suite 700, Ann Arbor, MI 48105, USA | en_US |
dc.contributor.affiliationum | Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA, Fax: (+1) 14734-615-2506 ; | en_US |
dc.identifier.pmid | 17523182 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56102/1/1245_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/smll.200700054 | en_US |
dc.identifier.source | Small | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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