Phase II trial of carboplatin, gemcitabine, and capecitabine in patients with carcinoma of unknown primary site Presented in part at the 41st Annual Meeting of the American Society of Clinical Oncology, Orlando, Florida, May 13–17, 2005. Written informed consent was obtained from all patients before initiation of therapy.
dc.contributor.author | Schneider, Bryan J. | en_US |
dc.contributor.author | El-Rayes, Bassel F. | en_US |
dc.contributor.author | Muler, Jeffrey H. | en_US |
dc.contributor.author | Philip, Philip A. | en_US |
dc.contributor.author | Kalemkerian, Gregory P. | en_US |
dc.contributor.author | Griffith, Kent A. | en_US |
dc.contributor.author | Zalupski, Mark M. | en_US |
dc.date.accessioned | 2007-09-20T18:57:54Z | |
dc.date.available | 2008-09-08T14:25:12Z | en_US |
dc.date.issued | 2007-08-15 | en_US |
dc.identifier.citation | Schneider, Bryan J.; El-Rayes, Basil; Muler, Jeffery H.; Philip, Philip A.; Kalemkerian, Gregory P.; Griffith, Kent A.; Zalupski, Mark M. (2007)."Phase II trial of carboplatin, gemcitabine, and capecitabine in patients with carcinoma of unknown primary site Presented in part at the 41st Annual Meeting of the American Society of Clinical Oncology, Orlando, Florida, May 13–17, 2005. Written informed consent was obtained from all patients before initiation of therapy. ." Cancer 110(4): 770-775. <http://hdl.handle.net/2027.42/56111> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56111 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17594717&dopt=citation | en_US |
dc.description.abstract | BACKGROUND. The purposes of this study were to evaluate efficacy and toxicity of the combination of carboplatin, gemcitabine, and capecitabine in patients with carcinoma of unknown primary site (CUP). METHODS. Patients with CUP received carboplatin AUC 5 mg/mL a minute intravenously Day 1, gemcitabine 1000 mg/m 2 intravenously Days 1 and 8, and capecitabine 1600 mg/m 2 orally in divided doses, Days 1–14 of a 21-day cycle for up to 8 cycles. The primary endpoint of the study was objective response rate by intent-to-treat analysis. RESULTS. Thirty-three patients were treated (median age, 58 years; men:women ratio, 19:14). Most patients had a baseline performance status of 1. The objective response rate was 39.4% (95% CI, 22.9%–57.9%) in all patients, 36.4% in 22 patients with well to moderately differentiated adenocarcinoma, and 40.0% in 20 patients with liver metastases. Median progression-free survival time was 6.2 months (95% CI, 5.4%–8.0%), and median survival time was 7.6 months (95% CI, 6.3–14.1). One and 2-year survival rates were 35.6% and 14.2%, respectively. The most frequent grade ≥3 adverse events were neutropenia (67%), thrombocytopenia (48%), and anemia (33%). CONCLUSIONS. The combination of carboplatin, gemcitabine, and capecitabine is active in CUP, especially in patients with liver metastases. This regimen may be a potential therapy for CUP patients with good performance status, particularly those with a suspected origin below the diaphragm. Cancer 2007; 110:770–5. © 2007 American Cancer Society. | en_US |
dc.format.extent | 95958 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Phase II trial of carboplatin, gemcitabine, and capecitabine in patients with carcinoma of unknown primary site Presented in part at the 41st Annual Meeting of the American Society of Clinical Oncology, Orlando, Florida, May 13–17, 2005. Written informed consent was obtained from all patients before initiation of therapy. | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan ; Fax: (734) 647-8792 ; University of Michigan, C361 MIB, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0848 | en_US |
dc.contributor.affiliationum | Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Biostatistics Core Facility, University of Michigan Cancer Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Division of Hematology/Oncology, Karmanos Cancer Institute, Detroit, Michigan | en_US |
dc.contributor.affiliationother | Division of Hematology/Oncology, Karmanos Cancer Institute, Detroit, Michigan | en_US |
dc.identifier.pmid | 17594717 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56111/1/22857_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/cncr.22857 | en_US |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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