Characterization of progenitor domains in the developing mouse thalamus
dc.contributor.author | Vue, Tou Yia | en_US |
dc.contributor.author | Aaker, Joshua | en_US |
dc.contributor.author | Taniguchi, Aya | en_US |
dc.contributor.author | Kazemzadeh, Christina | en_US |
dc.contributor.author | Skidmore, Jennifer M. | en_US |
dc.contributor.author | Martin, Donna M. | en_US |
dc.contributor.author | Martin, James F. | en_US |
dc.contributor.author | Treier, Mathias | en_US |
dc.contributor.author | Nakagawa, Yasushi | en_US |
dc.date.accessioned | 2007-09-20T18:59:15Z | |
dc.date.available | 2008-11-05T15:05:43Z | en_US |
dc.date.issued | 2007-11-01 | en_US |
dc.identifier.citation | Vue, Tou Yia; Aaker, Joshua; Taniguchi, Aya; Kazemzadeh, Christina; Skidmore, Jennifer M.; Martin, Donna M.; Martin, James F.; Treier, Mathias; Nakagawa, Yasushi (2007)."Characterization of progenitor domains in the developing mouse thalamus." The Journal of Comparative Neurology 505(1): 73-91. <http://hdl.handle.net/2027.42/56116> | en_US |
dc.identifier.issn | 0021-9967 | en_US |
dc.identifier.issn | 1096-9861 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56116 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17729296&dopt=citation | |
dc.description.abstract | To understand the molecular basis of the specification of thalamic nuclei, we analyzed the expression patterns of various transcription factors and defined progenitor cell populations in the embryonic mouse thalamus. We show that the basic helix-loop-helix (bHLH) transcription factor Olig3 is expressed in the entire thalamic ventricular zone and the zona limitans intrathalamica (ZLI). Next, we define two distinct progenitor domains within the thalamus, which we name pTH-R and pTH-C, located caudal to the ZLI. pTH-R is immediately caudal to the ZLI and expresses Nkx2.2, Mash1, and Olig3. pTH-C is caudal to pTH-R and expresses Ngn1, Ngn2, and Olig3. Short-term lineage analysis of Olig3-, Mash1-, Ngn1-, and Ngn2-expressing progenitor cells as well as tracing the Pitx2 cell lineage suggests that pTH-C is the only major source of thalamic nuclei containing neurons that project to the cerebral cortex, whereas pTH-R and ZLI are likely to produce distinct postmitotic populations outside of the cortex-projecting part of the thalamus. To determine if pTH-C is composed of subdomains, we characterized expression of the homeodomain protein Dbx1 and the bHLH protein Olig2. We show that Dbx1 is expressed in caudodorsal-high to rostroventral-low gradient within pTH-C. Analysis of heterozygous Dbx1 nlslacZ knockin mice demonstrated that Dbx1-expressing progenitors preferentially give rise to caudodorsal thalamic nuclei. Olig2 is expressed in an opposite gradient within pTH-C to that of Dbx1. These results establish the molecular heterogeneity within the progenitor cells of the thalamus, and suggest that such heterogeneity contributes to the specification of thalamic nuclei. J. Comp. Neurol. 505:73–91, 2007. © 2007 Wiley-Liss, Inc. | en_US |
dc.format.extent | 2797500 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Characterization of progenitor domains in the developing mouse thalamus | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationother | Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 ; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455 ; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 | en_US |
dc.contributor.affiliationother | Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 ; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455 | en_US |
dc.contributor.affiliationother | Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 ; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455 | en_US |
dc.contributor.affiliationother | Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 ; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455 | en_US |
dc.contributor.affiliationother | Institute of Biosciences and Technology, Texas A&M Systems Health Science Center, College Station, Texas | en_US |
dc.contributor.affiliationother | Developmental Biology Unit, EMBL, Heidelberg, Germany | en_US |
dc.contributor.affiliationother | Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 ; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455 ; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 ; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455 | en_US |
dc.identifier.pmid | 17729296 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56116/1/21467_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/cne.21467 | en_US |
dc.identifier.source | The Journal of Comparative Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.