Characterization of progenitor domains in the developing mouse thalamus

Deep Blue Home

Show simple item record

dc.contributor.author Vue, Tou Yia en_US
dc.contributor.author Aaker, Joshua en_US
dc.contributor.author Taniguchi, Aya en_US
dc.contributor.author Kazemzadeh, Christina en_US
dc.contributor.author Skidmore, Jennifer M. en_US
dc.contributor.author Martin, Donna M. en_US
dc.contributor.author Martin, James F. en_US
dc.contributor.author Treier, Mathias en_US
dc.contributor.author Nakagawa, Yasushi en_US
dc.date.accessioned 2007-09-20T18:59:15Z
dc.date.available 2008-11-05T15:05:43Z en_US
dc.date.issued 2007-11-01 en_US
dc.identifier.citation Vue, Tou Yia; Aaker, Joshua; Taniguchi, Aya; Kazemzadeh, Christina; Skidmore, Jennifer M.; Martin, Donna M.; Martin, James F.; Treier, Mathias; Nakagawa, Yasushi (2007)."Characterization of progenitor domains in the developing mouse thalamus." The Journal of Comparative Neurology 505(1): 73-91. <http://hdl.handle.net/2027.42/56116> en_US
dc.identifier.issn 0021-9967 en_US
dc.identifier.issn 1096-9861 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/56116
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17729296&dopt=citation
dc.description.abstract To understand the molecular basis of the specification of thalamic nuclei, we analyzed the expression patterns of various transcription factors and defined progenitor cell populations in the embryonic mouse thalamus. We show that the basic helix-loop-helix (bHLH) transcription factor Olig3 is expressed in the entire thalamic ventricular zone and the zona limitans intrathalamica (ZLI). Next, we define two distinct progenitor domains within the thalamus, which we name pTH-R and pTH-C, located caudal to the ZLI. pTH-R is immediately caudal to the ZLI and expresses Nkx2.2, Mash1, and Olig3. pTH-C is caudal to pTH-R and expresses Ngn1, Ngn2, and Olig3. Short-term lineage analysis of Olig3-, Mash1-, Ngn1-, and Ngn2-expressing progenitor cells as well as tracing the Pitx2 cell lineage suggests that pTH-C is the only major source of thalamic nuclei containing neurons that project to the cerebral cortex, whereas pTH-R and ZLI are likely to produce distinct postmitotic populations outside of the cortex-projecting part of the thalamus. To determine if pTH-C is composed of subdomains, we characterized expression of the homeodomain protein Dbx1 and the bHLH protein Olig2. We show that Dbx1 is expressed in caudodorsal-high to rostroventral-low gradient within pTH-C. Analysis of heterozygous Dbx1 nlslacZ knockin mice demonstrated that Dbx1-expressing progenitors preferentially give rise to caudodorsal thalamic nuclei. Olig2 is expressed in an opposite gradient within pTH-C to that of Dbx1. These results establish the molecular heterogeneity within the progenitor cells of the thalamus, and suggest that such heterogeneity contributes to the specification of thalamic nuclei. J. Comp. Neurol. 505:73–91, 2007. © 2007 Wiley-Liss, Inc. en_US
dc.format.extent 2797500 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Neuroscience, Neurology and Psychiatry en_US
dc.title Characterization of progenitor domains in the developing mouse thalamus en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Neurosciences en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Departments of Pediatrics and Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 en_US
dc.contributor.affiliationum Departments of Pediatrics and Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 en_US
dc.contributor.affiliationother Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 ; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455 ; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 en_US
dc.contributor.affiliationother Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 ; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455 en_US
dc.contributor.affiliationother Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 ; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455 en_US
dc.contributor.affiliationother Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 ; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455 en_US
dc.contributor.affiliationother Institute of Biosciences and Technology, Texas A&M Systems Health Science Center, College Station, Texas en_US
dc.contributor.affiliationother Developmental Biology Unit, EMBL, Heidelberg, Germany en_US
dc.contributor.affiliationother Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 ; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455 ; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 ; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455 en_US
dc.identifier.pmid 17729296
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/56116/1/21467_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/cne.21467 en_US
dc.identifier.source The Journal of Comparative Neurology en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
 Show simple item record

This item appears in the following Collection(s)


Search Deep Blue

Browse by

My Account

Information

Coming Soon


MLibrary logo