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dc.contributor.authorLevin, Albert M.en_US
dc.contributor.authorZuhlke, Kimberly A.en_US
dc.contributor.authorRay, Anna M.en_US
dc.contributor.authorCooney, Kathleen A.en_US
dc.contributor.authorDouglas, Julie A.en_US
dc.date.accessioned2007-09-20T19:02:01Z
dc.date.available2008-11-05T15:05:43Zen_US
dc.date.issued2007-10-01en_US
dc.identifier.citationLevin, Albert M.; Zuhlke, Kimberly A.; Ray, Anna M.; Cooney, Kathleen A.; Douglas, Julie A. (2007)."Sequence variation in Α-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer." The Prostate 67(14): 1507-1513. <http://hdl.handle.net/2027.42/56126>en_US
dc.identifier.issn0270-4137en_US
dc.identifier.issn1097-0045en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/56126
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17683075&dopt=citation
dc.description.abstractBACKGROUND Expression of the Α-methylacyl-CoA racemase ( AMACR ) gene has been established as a sensitive and specific biomarker for the diagnosis of prostate cancer. An initial study has also suggested that the risk of familial (but not sporadic) prostate cancer may be associated with germline variation in the AMACR gene. METHODS In a study of brothers discordant for the diagnosis of prostate cancer (including 449 affected and 394 unaffected men) from 332 familial and early-onset prostate cancer families, we used conditional logistic regression and family-based association tests to investigate the association between prostate cancer and five single nucleotide polymorphisms (SNPs) tagging common haplotype variation within the coding and regulatory regions of AMACR . RESULTS The strongest evidence for prostate cancer association was for SNP rs3195676, with an estimated odds ratio of 0.58 (95% confidence interval = 0.38–0.90; P  = 0.01 for a recessive model). This non-synonymous SNP (nsSNP) results in a methionine-to-valine substitution at codon 9 (M9V) in exon 2 of the AMACR gene. Three additional nsSNPs showed suggestive evidence for prostate cancer association ( P  ≤ 0.10). CONCLUSIONS Our results confirm an initial report of association between the AMACR gene and the risk of familial prostate cancer. These findings emphasize the value of studying early-onset and familial prostate cancer when attempting to identify genetic variation associated with prostate cancer. Prostate 67: 1507–1513, 2007. © 2007 Wiley-Liss, Inc.en_US
dc.format.extent126736 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCancer Research, Oncology and Pathologyen_US
dc.titleSequence variation in Α-methylacyl-CoA racemase and risk of early-onset and familial prostate canceren_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan ; Department of Urology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan ; Department of Human Genetics, University of Michigan, Buhl Building, Room 5912, Ann Arbor, MI 48109-0618.en_US
dc.identifier.pmid17683075
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/56126/1/20642_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/pros.20642en_US
dc.identifier.sourceThe Prostateen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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