An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease
dc.contributor.author | Dyson, Greg | en_US |
dc.contributor.author | Frikke-Schmidt, Ruth | en_US |
dc.contributor.author | Nordestgaard, Børge G. | en_US |
dc.contributor.author | Tybjæ;rg-Hansen, Anne | en_US |
dc.contributor.author | Sing, Charles F. | en_US |
dc.date.accessioned | 2007-09-20T19:05:03Z | |
dc.date.available | 2008-09-08T14:25:14Z | en_US |
dc.date.issued | 2007-09 | en_US |
dc.identifier.citation | Dyson, Greg; Frikke-Schmidt, Ruth; Nordestgaard, BØrge G.; TybjÆ;rg-Hansen, Anne; Sing, Charles F. (2007)."An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease." Genetic Epidemiology 31(6): 515-527. <http://hdl.handle.net/2027.42/56137> | en_US |
dc.identifier.issn | 0741-0395 | en_US |
dc.identifier.issn | 1098-2272 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56137 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17436307&dopt=citation | en_US |
dc.description.abstract | Different combinations of genetic and environmental risk factors are known to contribute to the complex etiology of ischemic heart disease (IHD) in different subsets of individuals. We employed the Patient Rule-Induction Method (PRIM) to select the combination of risk factors and risk factor values that identified each of 16 mutually exclusive partitions of individuals having significantly different levels of risk of IHD. PRIM balances two competing objectives: (1) finding partitions where the risk of IHD is high and (2) maximizing the number of IHD cases explained by the partitions. A sequential PRIM analysis was applied to data on the incidence of IHD collected over 8 years for a sample of 5,455 unrelated individuals from the Copenhagen City Heart Study (CCHS) to assess the added value of variation in two candidate susceptibility genes beyond the traditional, lipid and body mass index risk factors for IHD. An independent sample of 362 unrelated individuals also from the city of Copenhagen was used to test the model obtained for each of the hypothesized partitions. Genet. Epidemiol . 2007. © 2007 Wiley-Liss, Inc. | en_US |
dc.format.extent | 286477 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Genetics | en_US |
dc.title | An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan ; Department of Human Genetics, University of Michigan, 1241 E. Catherine Street, 5928 Buhl Building, Ann Arbor, MI 48109-0618, USA | en_US |
dc.contributor.affiliationother | Department of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark | en_US |
dc.contributor.affiliationother | Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark ; The Copenhagen City Heart Study, Bispebjerg University Hospital, Copenhagen, Denmark | en_US |
dc.contributor.affiliationother | Department of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark ; The Copenhagen City Heart Study, Bispebjerg University Hospital, Copenhagen, Denmark | en_US |
dc.identifier.pmid | 17436307 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56137/1/20225_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/gepi.20225 | en_US |
dc.identifier.source | Genetic Epidemiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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