Health-related quality of life in adult survivors of childhood Wilms tumor or neuroblastoma: A report from the childhood cancer survivor study
dc.contributor.author | Nathan, Paul C. | en_US |
dc.contributor.author | Ness, Kirsten K. | en_US |
dc.contributor.author | Greenberg, Mark L. | en_US |
dc.contributor.author | Hudson, Melissa M. | en_US |
dc.contributor.author | Wolden, Suzanne | en_US |
dc.contributor.author | Davidoff, Andrew | en_US |
dc.contributor.author | Laverdiere, Caroline | en_US |
dc.contributor.author | Mertens, Ann C. | en_US |
dc.contributor.author | Whitton, John | en_US |
dc.contributor.author | Robison, Leslie L. | en_US |
dc.contributor.author | Zeltzer, Lonnie | en_US |
dc.contributor.author | Gurney, James G. | en_US |
dc.date.accessioned | 2007-09-20T19:13:28Z | |
dc.date.available | 2008-11-05T15:05:43Z | en_US |
dc.date.issued | 2007-10-15 | en_US |
dc.identifier.citation | Nathan, Paul C.; Ness, Kirsten K.; Greenberg, Mark L.; Hudson, Melissa; Wolden, Suzanne; Davidoff, Andrew; Laverdiere, Caroline; Mertens, Ann; Whitton, John; Robison, Leslie L.; Zeltzer, Lonnie; Gurney, James G. (2007)."Health-related quality of life in adult survivors of childhood Wilms tumor or neuroblastoma: A report from the childhood cancer survivor study." Pediatric Blood & Cancer 49(5): 704-715. <http://hdl.handle.net/2027.42/56166> | en_US |
dc.identifier.issn | 1545-5009 | en_US |
dc.identifier.issn | 1545-5017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56166 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16830322&dopt=citation | |
dc.description.abstract | Background Long-term survivors of Wilms tumor and neuroblastoma may experience significant late adverse effects from their disease and its therapy. Little is known, however, about the health-related quality of life experienced by these survivors. Procedure Health-related quality of life, measured by the 36-Item Short Form Health Survey (SF-36), was assessed from self-report in adult survivors of Wilms tumor (N = 654) and neuroblastoma (N = 432) who participated in the Childhood Cancer Survivor Study. Results More than 90% of the study population was 18–34 years old at interview, and 58% were females. There was no significant difference on any SF-36 subscale or summary scale between the two diagnostic groups. On average, survivors reported no decrement on the Physical Component Summary scale of the SF-36 when compared to population norms. However, both groups scored significantly below the population mean score (50) on the Mental Component Summary Scale of the SF-36 (Wilms tumor mean = 41.66, standard error = 2.19, P < 0.0001; neuroblastoma mean = 42.41, standard error = 2.23, P < 0.0001) reflecting decreased emotional health. Independent risk factors for lower scores on this scale included female gender, Native American race, unemployment, and household income below $20,000. Conclusions Adult survivors of childhood Wilms tumor and neuroblastoma do not differ from population norms on most health-related quality of life (HRQL) measures. These data, however, indicate that the emotional well being of adult survivors may be compromised. Health care providers should be aware of the risk of adverse outcomes in emotional health even many years after treatment and cure. Pediatr Blood Cancer 2007;49:704–715. © 2006 Wiley-Liss, Inc. | en_US |
dc.format.extent | 150291 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Health-related quality of life in adult survivors of childhood Wilms tumor or neuroblastoma: A report from the childhood cancer survivor study | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, Child Health Evaluation and Research Unit, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | The Hospital for Sick Children, Toronto, Ontario, Canada ; The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada. | en_US |
dc.contributor.affiliationother | University of Minnesota Cancer Center, Minneapolis, Minnesota | en_US |
dc.contributor.affiliationother | The Hospital for Sick Children, Toronto, Ontario, Canada | en_US |
dc.contributor.affiliationother | St. Jude Children's Research Hospital, Memphis, Tennessee | en_US |
dc.contributor.affiliationother | Memorial Sloan Kettering Cancer Center, New York, New York | en_US |
dc.contributor.affiliationother | St. Jude Children's Research Hospital, Memphis, Tennessee | en_US |
dc.contributor.affiliationother | Hospital Sainte Justine, Montreal, Quebec, Canada | en_US |
dc.contributor.affiliationother | University of Minnesota Cancer Center, Minneapolis, Minnesota | en_US |
dc.contributor.affiliationother | Fred Hutchison Cancer Research Center, Seattle, Washington | en_US |
dc.contributor.affiliationother | St. Jude Children's Research Hospital, Memphis, Tennessee | en_US |
dc.contributor.affiliationother | UCLA School of Medicine, Los Angeles, California | en_US |
dc.identifier.pmid | 16830322 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56166/1/20949_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/pbc.20949 | en_US |
dc.identifier.source | Pediatric Blood & Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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