A molecular classification of congenital neutropenia syndromes
dc.contributor.author | Boxer, Laurence A. | en_US |
dc.contributor.author | Newburger, Peter E. | en_US |
dc.date.accessioned | 2007-09-20T19:13:43Z | |
dc.date.available | 2008-11-05T15:05:43Z | en_US |
dc.date.issued | 2007-10-15 | en_US |
dc.identifier.citation | Boxer, Laurence A.; Newburger, Peter E. (2007)."A molecular classification of congenital neutropenia syndromes." Pediatric Blood & Cancer 49(5): 609-614. <http://hdl.handle.net/2027.42/56167> | en_US |
dc.identifier.issn | 1545-5009 | en_US |
dc.identifier.issn | 1545-5017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56167 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17584878&dopt=citation | |
dc.description.abstract | Current knowledge on the molecular pathogenesis of severe congenital neutropenia indicates that the clinical diagnosis includes a heterogeneous group of disorders following different patterns of inheritance. Similarly, multifaceted syndromes associated with neutropenia can be classified molecularly, which in turn allows for a better understanding of the basis of the neutropenia. Many of the neutropenia disorders can be treated with G-CSF (filgrastim) to increase the neutrophil count, thereby reducing infection morbidity and mortality. In some instances hematopoietic stem cell transplantation remains the only curative treatment currently available. This review describes and classifies, on a molecular basis, both primary congenital neutropenia and multifaceted syndromes associated with neutropenia. Pediatr Blood Cancer 2007;49:609–614. © 2007 Wiley-Liss, Inc. | en_US |
dc.format.extent | 111680 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | A molecular classification of congenital neutropenia syndromes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Pediatric Hematology/Oncology, Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Departments of Pediatrics and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts ; Department of Pediatrics, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655. | en_US |
dc.identifier.pmid | 17584878 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56167/1/21282_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/pbc.21282 | en_US |
dc.identifier.source | Pediatric Blood & Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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