A molecular classification of congenital neutropenia syndromes

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dc.contributor.author Boxer, Laurence A. en_US
dc.contributor.author Newburger, Peter E. en_US
dc.date.accessioned 2007-09-20T19:13:43Z
dc.date.available 2008-11-05T15:05:43Z en_US
dc.date.issued 2007-10-15 en_US
dc.identifier.citation Boxer, Laurence A.; Newburger, Peter E. (2007)."A molecular classification of congenital neutropenia syndromes." Pediatric Blood & Cancer 49(5): 609-614. <http://hdl.handle.net/2027.42/56167> en_US
dc.identifier.issn 1545-5009 en_US
dc.identifier.issn 1545-5017 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/56167
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17584878&dopt=citation
dc.description.abstract Current knowledge on the molecular pathogenesis of severe congenital neutropenia indicates that the clinical diagnosis includes a heterogeneous group of disorders following different patterns of inheritance. Similarly, multifaceted syndromes associated with neutropenia can be classified molecularly, which in turn allows for a better understanding of the basis of the neutropenia. Many of the neutropenia disorders can be treated with G-CSF (filgrastim) to increase the neutrophil count, thereby reducing infection morbidity and mortality. In some instances hematopoietic stem cell transplantation remains the only curative treatment currently available. This review describes and classifies, on a molecular basis, both primary congenital neutropenia and multifaceted syndromes associated with neutropenia. Pediatr Blood Cancer 2007;49:609–614. © 2007 Wiley-Liss, Inc. en_US
dc.format.extent 111680 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Cancer Research, Oncology and Pathology en_US
dc.title A molecular classification of congenital neutropenia syndromes en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Pediatrics en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Division of Pediatric Hematology/Oncology, Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan en_US
dc.contributor.affiliationother Departments of Pediatrics and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts ; Department of Pediatrics, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655. en_US
dc.identifier.pmid 17584878
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/56167/1/21282_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/pbc.21282 en_US
dc.identifier.source Pediatric Blood & Cancer en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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